部分肌肉再支配能否保留未来的再支配潜力？
Does partial muscle reinnervation preserve future re-innervation potential?
作者信息
Isaacs Jonathan, Mallu Satya, Shall Mary, Patel Gaurangkumar, Shah Pooja, Shah Shalin, Feger Mark A, Graham Gordon, Pasula Nikhil
机构信息
Division of Hand Surgery, Department of Orthopaedic Surgery, Virginia Commonwealth University Medical Center, 1200 East Broad Street, Richmond, Virginia, 23298, USA.
Department of Physical Therapy, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA.
出版信息
Muscle Nerve. 2017 Dec;56(6):1143-1148. doi: 10.1002/mus.25571. Epub 2017 Mar 17.
INTRODUCTION
Late revision nerve surgery for incomplete motor recovery due to partial reinnervation would improve muscle function if all muscle fibers were protected from developing denervation atrophy.
METHODS
Sixty immature Sprague-Dawley rats underwent the following tibial nerve manipulations (n = 15/group): group A, partial denervation (two thirds of nerve resected and the remaining one third crushed), revision repair at 8 months; group B, partial denervation; group C, complete denervation, immediate reconstruction; group D, complete denervation, reconstruction at 8 months; and group E, control. Final testing at 11 months included muscle force, weight, and histology.
RESULTS
Muscle weight was significantly (P < 0.05) different among all groups (highest to lowest: E > B > C > A > D), and force was significantly lower in groups A and D compared with E. Muscle fiber cross-sectional area was statistically smaller in group A than in groups B, C, or E.
DISCUSSION
Partial reinnervation still allowed substantial muscle recovery, but it did not preserve the non-innervated muscle fibers. Muscle Nerve 56: 1143-1148, 2017.
引言
对于因部分神经再支配导致运动恢复不完全而进行的晚期修复性神经手术，如果能保护所有肌纤维不发生失神经萎缩，将改善肌肉功能。
方法
60只未成熟的Sprague-Dawley大鼠接受以下胫神经操作（每组n = 15只）：A组，部分去神经支配（切除三分之二的神经，其余三分之一压榨），8个月后进行修复；B组，部分去神经支配；C组，完全去神经支配，立即重建；D组，完全去神经支配，8个月后重建；E组，对照组。11个月时的最终测试包括肌肉力量、重量和组织学检查。
结果
所有组之间肌肉重量有显著差异（P < 0.05）（从高到低：E > B > C > A > D），A组和D组的力量明显低于E组。A组的肌纤维横截面积在统计学上小于B组、C组或E组。
讨论
部分神经再支配仍能使肌肉有显著恢复，但不能保留未受神经支配的肌纤维。《肌肉与神经》56: 1143 - 1148, 2017年。
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