根据性别、发病年龄和HLA - B51分型的韩国白塞病患者的临床表型
Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset, and HLA-B51.
作者信息
Ryu Hee Jung, Seo Mi Ryoung, Choi Hyo Jin, Baek Han Joo
机构信息
Department of Rheumatology, Gachon University Gil Medical Center, Incheon, Korea.
出版信息
Korean J Intern Med. 2018 Sep;33(5):1025-1031. doi: 10.3904/kjim.2016.202. Epub 2017 Jan 12.
BACKGROUND/AIMS: The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B51 have also been known as the factors that influence the clinical features of BD. The aim of this study is to investigate the clinical phenotypes of Korean patients who visited the rheumatology clinic with BD with respect to gender, onset age, and HLA-B51.
METHODS
Total 193 Korean patients (129 females and 64 males) fulfilling the international criteria for BD were retrospectively assessed.
RESULTS
The mean age at disease onset and disease duration of the BD patients were 32.2 ± 11.1 and 14.2 ± 9.3 years, retrospectively. Females suffered more frequently from genital ulcers (90.7% vs. 75.0%, p < 0.01), peripheral arthritis (67.4% vs. 43.8%, p < 0.01), and inf lammatory low back pain (38.8% vs. 23.4%, p = 0.03) than males, while skin involvement was more frequent in males than in females (90.6% vs. 75.2%, p = 0.01). The patients with late onset of BD (> 40 years) suffered from neurologic involvement (15.9% vs. 4.2%, p = 0.007) more frequently than those with early onset of BD. The patients with HLA-B51 showed earlier onset of disease than without HLA-B51 (28.3 ± 11.4 years vs. 33.8±11.6 years, p = 0.02) and the neurologic and gastrointestinal involvements were more frequent in the patients without HLA-B51 than with HLA-B51 (17.2% vs. 2.5%, p = 0.02 and 20.7% vs. 2.5%, p = 0.01, respectively).
CONCLUSION
The clinical phenotypes in Korean patients with BD may be influenced by gender, onset age and HLA-B51.
背景/目的：据报道，白塞病（BD）的临床表现因国家、地区和种族而异。性别、发病年龄和人类白细胞抗原（HLA）-B51也被认为是影响BD临床特征的因素。本研究旨在调查因BD就诊于风湿病门诊的韩国患者在性别、发病年龄和HLA - B51方面的临床表型。
方法
对符合BD国际标准的193例韩国患者（129例女性和64例男性）进行回顾性评估。
结果
回顾性分析显示，BD患者的平均发病年龄和病程分别为32.2±11.1岁和14.2±9.3岁。女性比男性更易出现生殖器溃疡（90.7%对75.0%，p<0.01）、外周关节炎（67.4%对43.8%，p<0.01）和炎性腰背痛（38.8%对23.4%，p = 0.03），而男性皮肤受累比女性更常见（90.6%对75.2%，p = 0.01）。BD晚发患者（>40岁）比早发患者更易出现神经受累（15.9%对4.2%，p = 0.007）。携带HLA - B51的患者发病早于未携带HLA - B51的患者（28.3±11.4岁对33.8±11.6岁，p = 0.02），未携带HLA - B51的患者神经和胃肠道受累比携带HLA - B51的患者更常见（分别为17.2%对2.5%，p = 0.02和20.7%对2.5%，p = 0.01）。
结论
韩国BD患者的临床表型可能受性别、发病年龄和HLA - B51影响。
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