Zhang Y G, Zhao S X, Zhou G D, Li W C, Ren W G, Du H J, Wang R Q, Nan Y M
Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
Department of Pathology and Hepatology Institution, Beijing 302 Hospital, Beijing 100039, China.
Zhonghua Gan Zang Bing Za Zhi. 2016 Dec 20;24(12):902-906. doi: 10.3760/cma.j.issn.1007-3418.2016.12.005.
To investigate the diagnostic value of FibroTouch and FibroScan for the stage of primary biliary cirrhosis (PBC). A total of 66 PBC patients who visited our hospital from January 2014 to March 2016 were enrolled, and all the patients underwent liver biopsy and FibroTouch and FibroScan tests. Liver stiffness measurement (LSM) was used to assess fibrosis degree, and the receiver operating characteristic (ROC) curve was used to compare the cut-off values, sensitivities, and specificities of these two methods in determining fibrosis stage. The Spearman rank correlation test was used to investigate the correlation between FibroTouch and FibroScan values. The correlation coefficients between FibroTouch or FibroScan values and fibrosis stage determined by liver biopsy were 0.904 and 0.880, respectively (both < 0.01). The cut-off values of FibroTouch in the diagnosis of PBC with fibrosis stages of ≥S1, ≥S2, ≥S3, and ≥S4 were 6.25 kPa, 9.05 kPa, 11.75 kPa, and 18.95 kPa, respectively, with sensitivities of 89.7%, 94.7%, 80.0%, and 80.0% and specificities of 100%, 100%, 87.0%, and 100%, respectively; the cut-off values of FibroScan were 6.05 kPa, 8.85 kPa, 12.40 kPa, and 16.20 kPa, respectively, with sensitivities of 96.4%, 88.6%, 76.2%, and 100% and specificities of 77.8%, 100%, 86.4%, and 93.0%, respectively. There were no significant differences in the diagnostic performance between FibroTouch and FibroScan in determining fibrosis stage [≥S1 ( = 0.109), ≥S2 ( = 0.853), ≥S3 ( = 0.387), ≥S4 ( = 0.224)]. FibroTouch and FibroScan can be used as noninvasive diagnostic tools for the determination of fibrosis stage and the monitoring of disease progression in PBC patients and have good sensitivity and specificity.
探讨FibroTouch和FibroScan对原发性胆汁性肝硬化（PBC）分期的诊断价值。纳入2014年1月至2016年3月期间来我院就诊的66例PBC患者，所有患者均接受了肝活检以及FibroTouch和FibroScan检测。采用肝脏硬度测量（LSM）评估纤维化程度，利用受试者工作特征（ROC）曲线比较这两种方法在确定纤维化分期时的临界值、敏感性和特异性。采用Spearman等级相关检验研究FibroTouch和FibroScan值之间的相关性。FibroTouch值和FibroScan值与肝活检确定的纤维化分期之间的相关系数分别为0.904和0.880（均<0.01）。FibroTouch诊断纤维化分期≥S1、≥S2、≥S3和≥S4的PBC时的临界值分别为6.25 kPa、9.05 kPa、11.75 kPa和18.95 kPa，敏感性分别为89.7%、94.7%、80.0%和80.0%，特异性分别为100%、100%、87.0%和100%；FibroScan的临界值分别为6.05 kPa、8.85 kPa、12.40 kPa和16.20 kPa，敏感性分别为96.4%、88.6%、76.2%和100%，特异性分别为77.8%、100%、86.4%和93.0%。在确定纤维化分期方面，FibroTouch和FibroScan的诊断性能无显著差异[≥S1（P = 0.109），≥S2（P = 0.853），≥S3（P = 0.387），≥S4（P = 0.224）]。FibroTouch和FibroScan可作为PBC患者纤维化分期测定及疾病进展监测的无创诊断工具，具有良好的敏感性和特异性。
