Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Discipline of Pathology, School of Medical Sciences and Bosch Institute, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Dig Liver Dis. 2019 Sep;51(9):1323-1329. doi: 10.1016/j.dld.2019.02.009. Epub 2019 Feb 28.
The aim of this study was to compare the diagnostic accuracy of the FibroTouch and FibroScan in patients with chronic liver disease (CLD) for staging fibrosis.
A prospective study was conducted in 435 CLD patients between 2014 and 2017. Index tests (FibroTouch, FibroScan, APRI, and FIB-4 score) and a reference standard (liver biopsy) were performed within one week.
The area under the receiver operating curve (AUROC) of the FibroTouch was similar with that of the FibroScan for the diagnosis of significant fibrosis, severe fibrosis, or cirrhosis; however, the AUROC of the FibroTouch was higher than that of APRI or FIB-4 (p < 0.001). There was a significant correlation (rho = 0.85, p < 0.001) between the FibroTouch and FibroScan for liver stiffness. The overall diagnostic accuracy of FibroTouch for significant fibrosis, severe fibrosis, or cirrhosis was 73.3%, 83.2%, or 84.1%, respectively. No significant differences between the FibroTouch and FibroScan were detected regarding the sensitivity, specificity, negative predictive value, positive predictive value, and accuracy. The optimal cut-off values for each stage of fibrosis were similar between the FibroTouch and FibroScan.
The FibroTouch is a valuable diagnostic tool for diagnosing liver fibrosis with good diagnostic accuracy which was comparable with that of the FibroScan, but superior to that of the APRI and FIB-4.
本研究旨在比较 FibroTouch 和 FibroScan 在慢性肝病 (CLD) 患者中用于纤维化分期的诊断准确性。
在 2014 年至 2017 年间，对 435 名 CLD 患者进行了前瞻性研究。在一周内进行了指数测试 (FibroTouch、FibroScan、APRI 和 FIB-4 评分) 和参考标准 (肝活检)。
FibroTouch 的接收器操作特征曲线下面积 (AUROC) 与 FibroScan 诊断显著纤维化、严重纤维化或肝硬化的 AUROC 相似；然而，FibroTouch 的 AUROC 高于 APRI 或 FIB-4 (p<0.001)。FibroTouch 与 FibroScan 之间的肝硬度存在显著相关性 (rho=0.85，p<0.001)。FibroTouch 对显著纤维化、严重纤维化或肝硬化的总体诊断准确性分别为 73.3%、83.2%或 84.1%。FibroTouch 和 FibroScan 在灵敏度、特异性、阴性预测值、阳性预测值和准确性方面没有显著差异。两种方法的每个纤维化阶段的最佳截断值相似。
FibroTouch 是一种有价值的诊断工具，可用于诊断肝纤维化，其诊断准确性良好，与 FibroScan 相当，但优于 APRI 和 FIB-4。
