Department of Gastroenterology, Fırat University School of Medicine, Elazığ, Türkiye.
Department of Gastroenterology, Karaman State Hospital, Karaman, Türkiye.
Turk J Gastroenterol. 2024 Jun 6;35(8):634-642. doi: 10.5152/tjg.2024.23531.
The presence of liver fibrosis is the most important indicator of progression to cirrhosis. Noninvasive measurement of liver stiffness is crucial for detecting fibrosis. Vibration-controlled transient elastography is one of the most useful methods for this purpose. We aimed to compare the liver stiffness and steatosis measurements with iLivTouch© and the FibroScan© elastography devices Two hundred thirty-seven consecutive adult patients with chronic hepatitis were included in the study. The liver stiffness and steatosis were measured with iLivTouch and FibroScan on the same day. Thirty-one patients had liver biopsies on the same day with elastography procedures. The diagnostic performances of iLivTouch and FibroScan were compared to aspartate aminotransferase to platelet ratio index (APRI), Fibrosis-4 (FIB-4), and nonalcoholic fatty liver disease fibrosis score (NFS). The liver stiffness measurements obtained using iLivTouch and FibroScan had median value of 10.3 (ranging from 2.9 to 46.3) and 7.2 (ranging from 2.5 to 75), respectively. The mean steatosis measurements using ultrasound attenuation parameter with iLivTouch were 245.51 ± 45.79, while the mean controlled attenuation parameter measurements using FibroScan were 259.37 ± 75.0. In subgroup analysis, the AUC of iLivTouch on detecting signiicant fibrosis [0.83, (P = .002)] was minimally higher than other noninvasive methods [0.82 for NFS (P = .003), 0.80 for FibroScan (P = .006), 0.68 for FIB-4 (P = .089), and 0.53 for APRI (P = .76)]. The stiffness and steatosis measurements with iLivTouch and FibroScan were not similar. The accuracy of iLivTouch in detecting significant and advanced fibrosis was minimally higher. Large clinical trials are necessary to support these findings.
肝脏纤维化的存在是向肝硬化进展的最重要指标。非侵入性测量肝硬度对于检测纤维化至关重要。振动控制瞬态弹性成像 (Vibration-controlled transient elastography) 是为此目的最有用的方法之一。我们旨在比较 iLivTouch© 和 FibroScan© 弹性成像设备测量的肝硬度和脂肪变性。
这项研究纳入了 237 名连续的慢性乙型肝炎成年患者。当天使用 iLivTouch 和 FibroScan 测量肝硬度和脂肪变性。当天有 31 名患者进行了肝活检和弹性成像检查。将 iLivTouch 和 FibroScan 的诊断性能与天冬氨酸氨基转移酶血小板比值指数 (APRI)、纤维化-4 (FIB-4) 和非酒精性脂肪性肝病纤维化评分 (NFS) 进行比较。
使用 iLivTouch 和 FibroScan 测量的肝硬度中位数分别为 10.3 (范围为 2.9 至 46.3) 和 7.2 (范围为 2.5 至 75)。使用 iLivTouch 测量的超声衰减参数的平均脂肪变性值为 245.51 ± 45.79，而使用 FibroScan 测量的受控衰减参数的平均脂肪变性值为 259.37 ± 75.0。在亚组分析中，iLivTouch 检测显著纤维化的 AUC[0.83，(P =.002)]略高于其他非侵入性方法[0.82 用于 NFS (P =.003)、0.80 用于 FibroScan (P =.006)、0.68 用于 FIB-4 (P =.089) 和 0.53 用于 APRI (P =.76)]。iLivTouch 和 FibroScan 测量的肝硬度和脂肪变性不相似。iLivTouch 检测显著和晚期纤维化的准确性略高。需要进行大型临床试验来支持这些发现。
