Hurley Susan, Hertz Andrew, Nelson David O, Layefsky Michael, Von Behren Julie, Bernstein Leslie, Deapen Dennis, Reynolds Peggy
Cancer Prevention Institute of California, 2001 Center Street, Suite 700, Berkeley, CA, USA.
Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA, USA.
Am J Epidemiol. 2017 Feb 1;185(3):238-246. doi: 10.1093/aje/kww108.
Large-scale environmental epidemiologic studies often rely on exposure estimates based on linkage to residential addresses. This approach, however, is limited by the lack of residential histories typically available for study participants. Our objective was to evaluate the feasibility of using address data from LexisNexis (a division of RELX, Inc., Dayton, Ohio), a commercially available credit reporting company, to construct residential histories for participants in the California Teachers Study (CTS), a prospective cohort study initiated in 1995-1996 to study breast cancer (n = 133,479). We evaluated the degree to which LexisNexis could provide retrospective addresses prior to study enrollment, as well as the concordance with existing prospective CTS addresses ascertained at the time of the completion of 4 self-administered questionnaires. For approximately 80% of CTS participants, LexisNexis provided at least 1 retrospective address, including nearly 25,000 addresses completely encompassed by time periods prior to enrollment. This approach more than doubled the proportion of the study population for whom we had an address of residence during the childbearing years-an important window of susceptibility for breast cancer risk. While overall concordance between the prospective addresses contained in these 2 data sources was good (85%), it was diminished among black women and women under the age of 40 years.
大规模环境流行病学研究通常依赖于基于与居住地址关联的暴露估计。然而，这种方法受到研究参与者通常缺乏居住史的限制。我们的目标是评估使用来自LexisNexis（RELX公司的一个部门，位于俄亥俄州代顿市）的地址数据的可行性，LexisNexis是一家商业信用报告公司，为加利福尼亚教师研究（CTS）的参与者构建居住史，CTS是一项于1995 - 1996年启动的前瞻性队列研究，旨在研究乳腺癌（n = 133,479）。我们评估了LexisNexis能够在研究入组前提供回顾性地址的程度，以及与在完成4份自填问卷时确定的现有前瞻性CTS地址的一致性。对于大约80%的CTS参与者，LexisNexis提供了至少1个回顾性地址，其中近25,000个地址完全涵盖在入组前的时间段内。这种方法使我们在育龄期有居住地址的研究人群比例增加了一倍多，育龄期是乳腺癌风险的一个重要易感窗口。虽然这两个数据源中包含的前瞻性地址之间的总体一致性良好（85%），但在黑人女性和40岁以下女性中一致性有所降低。
