van Hoof M, de Geus J P, Roos M, Brown C, Jacobs H, Ploegh H
Department of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam.
Immunogenetics. 1989;30(5):330-4. doi: 10.1007/BF02425272.
The sequence of a feline class I pseudogene and its comparison with class I genes from other species is presented. The gene isolated is a pseudogene because of the presence of four stop codons and two frame shift mutations in the first- and second-domain encoding exons, as well as a mutation in a splice acceptor site in the third intron. By sequence comparison with the other class I sequences determined to date, the FLA pseudogene is most closely related to the HLA-A locus products (88% nucleotide identity.
本文展示了猫科动物I类假基因的序列及其与其他物种I类基因的比较。分离出的该基因是一个假基因，原因是在编码第一和第二结构域的外显子中存在四个终止密码子和两个移码突变，以及在第三个内含子的剪接受体位点存在一个突变。通过与迄今确定的其他I类序列进行序列比较，FLA假基因与HLA - A位点产物关系最为密切（核苷酸同一性为88%）。
