Moore K W, Sher B T, Sun Y H, Eakle K A, Hood L
Science. 1982 Feb 5;215(4533):679-82. doi: 10.1126/science.7058332.
The sequence of a gene, denoted 27.5, encoding a transplantation antigen for the BALB/c mouse has been determined. Gene transfer studies and comparison of the translated sequence with the partial amino acid sequence of the Ld transplantation antigen establish that gene 27.5 encodes an Ld polypeptide. A comparison of the gene 27.5 sequence with several complementary DNA sequences suggests that the BALB/c mouse may contain a number of closely related L-like genes. Gene 27.5 has eight exons that correlate with the structural domains of the transplantation antigen.
已确定一个名为27.5的基因序列，该基因编码BALB/c小鼠的一种移植抗原。基因转移研究以及将翻译后的序列与Ld移植抗原的部分氨基酸序列进行比较后发现，27.5基因编码一种Ld多肽。将27.5基因序列与多个互补DNA序列进行比较表明，BALB/c小鼠可能含有一些密切相关的L样基因。27.5基因有八个外显子，与移植抗原的结构域相关。
