主要组织相容性复合体的进化：从两栖动物非洲爪蟾中克隆主要组织相容性复合体I类分子
Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.
作者信息
Flajnik M F, Canel C, Kramer J, Kasahara M
机构信息
Department of Microbiology and Immunology, University of Miami, FL 33101.
出版信息
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):537-41. doi: 10.1073/pnas.88.2.537.
Abstract
Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like alpha-3 domain is more similar to the immunoglobulin-like domains of mammalian class II beta chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes is presented.
摘要
I类主要组织相容性复合体（MHC）cDNA克隆已从源自MHC纯合非洲爪蟾mRNA的表达文库中分离出来。核苷酸和预测的氨基酸序列与高等脊椎动物的MHC I类分子显示出明确的相似性。免疫球蛋白样α-3结构域与哺乳动物II类β链的免疫球蛋白样结构域比与哺乳动物I类分子的更相似，并给出了基于代表性MHC基因核苷酸序列的系统树。
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