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从世界首例成功的阴茎异体移植中吸取的经验教训。

Lessons learned from the world's first successful penis allotransplantation.

作者信息

Merwe Andre van der, Zarrabi Amir, Zühlke Alexander, Barsdorf Nicola, Moosa Rafique

机构信息

Division of Urology, Department of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.

Division of Plastic and Reconstructive surgery, Department of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.

出版信息

J Mater Sci Mater Med. 2017 Feb;28(2):27. doi: 10.1007/s10856-016-5836-9. Epub 2017 Jan 10.

DOI:10.1007/s10856-016-5836-9
PMID:28074434
Abstract

We performed a successful penis allotransplantation on 11 December 2014. Sharing the lessons learned might help more patients in need to be treated this way. We divided the project into manageable segments that was each overseen by an expert. The ethical review and conduct paved the way for a publically acceptable and successful project. Screening for a psychological stable recipient is important. The most difficult part of the project was finding a donor penis. This was successfully negotiated with the family of a brain dead donor by creating a neo-phallus for the donor, thereby maintaining the dignity of the donor. Working with transplant coordinators that are sympathetic to aphallic men is crucial. Surgeons versed in microvascular techniques is a critical part of the team. Transplant immunologists have to adapt to treat composite tissue transplantation patients.

摘要

2014年12月11日,我们成功实施了一例阴茎异体移植手术。分享所汲取的经验教训或许能帮助更多有需要的患者接受此类治疗。我们将该项目分成易于管理的部分,每个部分由一位专家负责监督。伦理审查和实施为一个公众可接受且成功的项目铺平了道路。筛选心理稳定的受者很重要。该项目最困难的部分是找到供体阴茎。通过为供体打造一个新阴茎,从而维护供体的尊严,我们与一名脑死亡供体的家属成功达成了协议。与同情阴茎缺失男性的移植协调员合作至关重要。精通微血管技术的外科医生是团队的关键组成部分。移植免疫学家必须做出调整以治疗复合组织移植患者。

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本文引用的文献

1
Calcineurin Inhibitor Nephrotoxicity Through the Lens of Longitudinal Histology: Comparison of Cyclosporine and Tacrolimus Eras.从纵向组织学角度看钙调神经磷酸酶抑制剂肾毒性:环孢素时代与他克莫司时代的比较
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Cutaneous alternariosis in a renal transplant recipient: a case report and literature review.
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Expect skin necrosis following penile replantation.阴茎再植后可能会出现皮肤坏死。
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A systematic review of conversion from calcineurin inhibitor to mammalian target of rapamycin inhibitors for maintenance immunosuppression in kidney transplant recipients.肾移植受者维持免疫抑制中从钙调神经磷酸酶抑制剂转换为雷帕霉素靶蛋白抑制剂的系统评价
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6
Using the dorsal, cavernosal, and external pudendal arteries for penile transplantation: technical considerations and perfusion territories.采用背侧、海绵体和阴部外动脉进行阴茎移植:技术考虑和灌注区域。
Plast Reconstr Surg. 2014 Jul;134(1):111e-119e. doi: 10.1097/PRS.0000000000000277.
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Arch Immunol Ther Exp (Warsz). 2011 Jun;59(3):157-9. doi: 10.1007/s00005-011-0121-6. Epub 2011 Mar 27.
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Clinical facial composite tissue allotransplantation: a review of the first four global experiences and future implications.临床面部复合组织同种异体移植:对前四个全球经验的回顾及未来影响。
Plast Reconstr Surg. 2010 Feb;125(2):538-546. doi: 10.1097/PRS.0b013e3181c722a8.
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Composite tissue allotransplantation.复合组织同种异体移植。
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