Narain Aditya, Kwok Chun Shing, Mamas Mamas A
Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK.
University Hospital of North Midlands, Stoke-on-Trent, UK.
Int J Clin Pract. 2017 Feb;71(2). doi: 10.1111/ijcp.12927. Epub 2017 Jan 10.
It is unclear whether consumption of sugar- or artificially sweetened beverages is independently associated with the development of metabolic syndrome. A systematic review and meta-analysis was performed to evaluate whether soft drink consumption is associated with the development of metabolic syndrome.
Medline and EMBASE were searched in November 2015 for studies which considered soft drink (sugar-sweetened beverage [SSB] and artificially sweetened beverage [ASB]) intake and risk of metabolic syndrome. Pooled risk ratios for adverse outcomes were calculated using inverse variance with a random effects model, and heterogeneity was assessed using the I statistic.
A total of 12 studies (eight cross-sectional, four prospective cohort studies) with 56 244 participants (age range 6-98 years) were included in the review. Our pooled analysis found that soft drink intake is associated with metabolic syndrome. This relationship is shown in cross-sectional studies of SSB consumption (RR 1.46, 95% CI 1.18-1.91) and both cross-sectional and prospective studies of ASB consumption (RR 2.45; 95% CI 1.15-5.14; RR 1.32, 95% CI 1.21-1.44, respectively). However, pooled results of prospective cohort studies of SSB consumption found no association between intake and risk of developing metabolic syndrome.
Sugar-sweetened beverage and ASB intake are both associated with metabolic syndrome. This association may be driven by the fact that soft drink intake serves as a surrogate for an unhealthy lifestyle, or an adverse cardiovascular risk factor profile.
尚不清楚饮用含糖饮料或人工甜味饮料是否与代谢综合征的发生独立相关。进行了一项系统评价和荟萃分析，以评估饮用软饮料是否与代谢综合征的发生有关。
2015年11月检索了Medline和EMBASE数据库，查找考虑软饮料（含糖饮料[SSB]和人工甜味饮料[ASB]）摄入量与代谢综合征风险的研究。使用随机效应模型的逆方差法计算不良结局的合并风险比，并使用I统计量评估异质性。
该评价纳入了12项研究（8项横断面研究、4项前瞻性队列研究），共56244名参与者（年龄范围6至98岁）。我们的汇总分析发现，饮用软饮料与代谢综合征有关。这种关系在含糖饮料消费的横断面研究（RR 1.46，95%CI 1.18 - 1.91）以及人工甜味饮料消费的横断面和前瞻性研究中均有体现（RR分别为2.45；95%CI 1.15 - 5.14；RR 1.32，95%CI 1.21 - 1.44）。然而，含糖饮料消费的前瞻性队列研究的汇总结果发现，摄入量与发生代谢综合征的风险之间无关联。
含糖饮料和人工甜味饮料的摄入均与代谢综合征有关。这种关联可能是由于饮用软饮料是不健康生活方式的一种体现，或是不良心血管危险因素谱的一个指标。
