Yu Q, Zhang J, Ni K, Qian X, Wang X
Division of Advanced Manufacturing, Graduate School at Shenzhen, Tsinghua University, Taoyuan Steet, Nanshan District, Shenzhen, 518055, China.
State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments and Mechanology, Tsinghua University, Qinghuayuan Street, Haidian District, Beijing, 100084, China.
J Mass Spectrom. 2017 Feb;52(2):109-115. doi: 10.1002/jms.3907.
A single gas-assisted electrospray ion source developed for ambient mass spectrometry is introduced in this paper. Simultaneous self-aspiration and electrospray could be achieved by using a constant sheath gas flow supplied from a mini air pump. A gas dynamic study of the spray module is carried out for structural optimization. The entire device exhibits a simplified design and has been systematically characterized through both simulated and experimental investigations. According to the results, the ion source exhibited satisfactory stability and the ability for quantitative operation in routine electrospray ionization mass spectrometry. Furthermore, the ion source can be operated as a desorption electrospray ionization source to perform direct desorption/ionization of the solid samples. The versatile source described here appears to provide a practical approach to perform ambient mass spectrometry analysis with unrestricted sampling operation, and the extensive gas dynamic studies together with the experimental characterization are believed to be helpful in building self-aspirating spray devices. Copyright © 2017 John Wiley & Sons, Ltd.
本文介绍了一种为常压质谱开发的单气体辅助电喷雾离子源。通过使用微型气泵提供的恒定鞘气流量，可实现同时自抽吸和电喷雾。对喷雾模块进行了气体动力学研究以优化结构。整个装置设计简化，并通过模拟和实验研究进行了系统表征。结果表明，该离子源在常规电喷雾电离质谱中表现出令人满意的稳定性和定量操作能力。此外，该离子源可作为解吸电喷雾电离源运行，对固体样品进行直接解吸/电离。这里描述的通用源似乎为进行无限制采样操作的常压质谱分析提供了一种实用方法，并且广泛的气体动力学研究以及实验表征被认为有助于构建自抽吸喷雾装置。版权所有© 2017约翰威立父子有限公司。
