Chen Qi, Pan Chenguang, Li Yajuan, Zhang Min, Gu Wei
College of Life Sciences, Shaanxi Normal University, No. 620, West Chang'an Avenue, Chang'an District, Xi'an 710119, China (
J Insect Sci. 2016 Feb 5;16(1). doi: 10.1093/jisesa/iev146. Print 2016.
Parabens are widely used as preservative substances in foods, pharmaceuticals, industrial products, and cosmetics. But several studies have cautioned that parabens have estrogenic or endocrine-disrupting properties. Drosophila melanogaster is an ideal model in vivo to detect the toxic effects of chemistry. The study was designed to assess the potential additive toxic effects of methylparaben (MP) and ethylparaben (EP) mixture (MP + EP) on lifespan and preadult development period in D. melanogaster The data revealed that the MP + EP can reduce the longevity of flies compared with the control group, consistent with a significant reduction in malondialdehyde levels and an increase in superoxide dismutase activities. Furthermore, MP + EP may have a greater toxic effect on longevity of flies than separate using with the same concentration. Additionally, parabens had a nonmonotonic dose-response effect on D. melanogaster preadult development period, showing that MP + EP delayed preadult development period compared with control group while individual MP or EP significantly shortened (P < 0.01) at low concentration (300 mg/l). In conclusion, MP + EP had the potential additive toxicity on lifespan and preadult development period for D. melanogaster.
对羟基苯甲酸酯被广泛用作食品、药品、工业产品和化妆品中的防腐剂。但多项研究警告称，对羟基苯甲酸酯具有雌激素或内分泌干扰特性。黑腹果蝇是检测化学物质毒性作用的理想体内模型。本研究旨在评估对羟基苯甲酸甲酯（MP）和对羟基苯甲酸乙酯（EP）混合物（MP + EP）对黑腹果蝇寿命和成虫前期发育时间的潜在联合毒性作用。数据显示，与对照组相比，MP + EP可缩短果蝇寿命，同时丙二醛水平显著降低，超氧化物歧化酶活性增加。此外，MP + EP对果蝇寿命的毒性作用可能大于相同浓度单独使用时的毒性作用。此外，对羟基苯甲酸酯对黑腹果蝇成虫前期发育时间具有非单调剂量反应效应，表明与对照组相比，MP + EP延迟了成虫前期发育时间，而在低浓度（300 mg/l）时，单独的MP或EP显著缩短了（P < 0.01）成虫前期发育时间。总之，MP + EP对黑腹果蝇的寿命和成虫前期发育时间具有潜在的联合毒性。
