Department of Mathematics and Science Education, Faculty of Education, Nevsehir Haci Bektas Veli University, Nevsehir 50300, Turkey.
Environ Toxicol Pharmacol. 2022 May;92:103856. doi: 10.1016/j.etap.2022.103856. Epub 2022 Mar 24.
Parabens are widely used as preservatives in pharmaceuticals, cosmetics, and food products. Ethylparaben (EP) and propylparaben (PP) are particularly preferred because of their bactericidal and fungicidal effects. Although generally described as safe compounds, many studies have reported that parabens have estrogenic and endocrine-disrupting properties. In the present study, the effects of EP and PP (50 mM, 100 mM and 200 mM) on Drosophila melanogaster development and fecundity were investigated. No differences were found in the pupation and maturation percentages in all concentrations of parabens (p > 0.05). However, it was found that the mean pupation and maturation times increased in all treatment groups (p < 0.05). A statistically significant decrease (p < 0.05) in the number of offspring of the 200 mM ethylparaben exposure group was observed. In all paraben groups, a significant reduction in mean fecundity was found compared to the control group (p < 0.05).
对苯二甲酸酯被广泛用作药品、化妆品和食品中的防腐剂。由于具有杀菌和抑菌作用，乙基对苯二甲酸酯（EP）和丙基对苯二甲酸酯（PP）特别受欢迎。尽管通常被描述为安全的化合物，但许多研究报告称对苯二甲酸酯具有雌激素和内分泌干扰特性。在本研究中，研究了 EP 和 PP（50 mM、100 mM 和 200 mM）对黑腹果蝇发育和繁殖的影响。在所有浓度的对苯二甲酸酯中，蛹化和成熟的百分比没有差异（p > 0.05）。然而，发现在所有处理组中，平均蛹化和成熟时间都增加了（p < 0.05）。200 mM 乙基对苯二甲酸酯暴露组的后代数量显著减少（p < 0.05）。与对照组相比，所有对苯二甲酸酯组的平均繁殖力均显著降低（p < 0.05）。
