Cazzo Everton, Gestic Martinho Antonio, Utrini Murillo Pimentel, Chaim Felipe David Mendonça, Geloneze Bruno, Pareja José Carlos, Chaim Elinton Adami, Magro Daniéla Oliveira
Department of Surgery.
Research Laboratory in Metabology and Diabetes (Limed), State University of Campinas - Unicamp, Campinas, SP, Brazil.
Arq Bras Cir Dig. 2016 Nov-Dec;29(4):272-275. doi: 10.1590/0102-6720201600040014.
Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone whose effects are predominantly trophic on the intestinal mucosa.
Critically evaluate the current literature on the influence of bariatric/metabolic surgery on the levels of GLP-2 and its potential clinical implications.
Narrative review through online research on the databases Medline and Lilacs. There were six prospective human studies, two cross-sectional human studies, and three experimental animal studies selected.
There is evidence demonstrating significant increase in the levels of GLP-2 following gastric bypass, Scopinaro operation, and sleeve gastrectomy. There are no differences between gastric bypass and sleeve gastrectomy in regards to the increase in the GLP-2 levels. There is no correlation between the postoperative levels of GLP-2 and the occurrence of adequate or insufficient postoperative weight loss.
GLP-2 plays significant roles on the regulation of nutrient absorption, permeability of gut mucosa, control of bone resorption, and regulation of satiety. The overall impact of these effects potentially exerts a significant adaptive or compensatory effect within the context of varied bariatric surgical techniques.
胰高血糖素样肽-2（GLP-2）是一种胃肠激素，其作用主要是对肠黏膜起营养作用。
严格评估目前关于减肥/代谢手术对GLP-2水平的影响及其潜在临床意义的文献。
通过对Medline和Lilacs数据库进行在线研究进行叙述性综述。共选取了六项前瞻性人体研究、两项横断面人体研究和三项实验动物研究。
有证据表明，胃旁路手术、斯科皮纳罗手术和袖状胃切除术后GLP-2水平显著升高。胃旁路手术和袖状胃切除术后GLP-2水平升高方面无差异。术后GLP-2水平与术后体重减轻充足或不足的发生情况之间无相关性。
GLP-2在营养吸收调节、肠黏膜通透性、骨吸收控制和饱腹感调节中起重要作用。在各种减肥手术技术的背景下，这些作用的总体影响可能会产生显著的适应性或补偿性作用。
