Fernandes Melina Ribeiro, Lima Nayara Vieira de, Rezende Karoline Silva, Santos Isabela Caroline Marques, Silva Iandara Schettert, Guimarães Rita de Cássia Avellaneda
Acta Cir Bras. 2016 Dec;31(12):840-844. doi: 10.1590/S0102-865020160120000010.
: To perform an integrative review of the main animal disease models in rodents used for obesity.
: Research was conducted in the CAPES Portal database using the following keywords "obesity animal models, diet and rodents", published between the years 2010 to 2016. We found 108 articles, of which 19 were selected and analyzed in full for this study.
: Larger part of publications occurred in the last 6 years, the rats (n = 10) were used in the same proportion mice (n = 10). The choice of male animals (n = 18) and age greater than 21 days (n = 17) showed a major highlight. The greater than 5 week follow-up period (n = 18) was the most applied. A High Fat Diet was the most used in studies (n = 18) .
: Male rodents continue to be considered the species most used in experimental studies to induce obesity, also was found variations of age to the beginning of the experiment. For the most part are follow-up time studies along with the use of High Fat Diet.
对用于肥胖研究的啮齿动物主要动物疾病模型进行综合综述。
在CAPES门户数据库中进行研究，使用以下关键词“肥胖动物模型、饮食与啮齿动物”，检索2010年至2016年间发表的文献。我们找到了108篇文章，其中19篇被选出来进行全文分析用于本研究。
大部分出版物发表于过去6年，大鼠（n = 10）和小鼠（n = 10）的使用比例相同。雄性动物（n = 18）和年龄大于21天（n = 17）的选择最为突出。随访期大于5周（n = 18）的应用最为广泛。高脂饮食是研究中最常用的（n = 18）。
雄性啮齿动物仍然被认为是实验研究中诱导肥胖最常用的物种，同时也发现实验开始时年龄存在差异。大部分研究是随访时间研究，并使用高脂饮食。
