Health Sciences Department, Universidade Federal de Lavras (UFLA), Lavras BR-37200-000, Brazil.
Veterinary Science Department, Universidade Federal de Lavras (UFLA), Lavras BR-37200-000, Brazil.
Nutrients. 2021 Nov 26;13(12):4250. doi: 10.3390/nu13124250.
Dietary fiber supplementation has been studied as a promising strategy in the treatment of obesity and its comorbidities. A systematic review and meta-analysis were performed to verify whether the consumption of yeast beta-glucan (BG) favors weight loss in obese and non-obese rodents. The PICO strategy was employed, investigating rodents (Population), subjected to the oral administration of yeast BG (Intervention) compared to animals receiving placebo (Comparison), evaluating body weight changes (Outcome), and based on preclinical studies (Study design). Two reviewers searched six databases and the grey literature. We followed the PRISMA 2020 guidelines, and the protocol was registered on PROSPERO (CRD42021267788). The search returned 2467 articles. Thirty articles were selected for full-text evaluation, and seven studies remained based on the eligibility criteria. The effects of BG intake on body weight were analyzed based on obese ( = 4 studies) and non-obese animals ( = 4 studies). Even though most studies on obese rodents (75%) indicated a reduction in body weight (qualitative analysis), the meta-analysis showed this was not significant (mean difference -1.35 g-95% CI -5.14:2.45). No effects were also observed for non-obese animals. We concluded that the ingestion of yeast BG barely affects the body weight of obese and non-obese animals.
膳食纤维补充已被研究作为治疗肥胖及其合并症的一种有前途的策略。进行了系统评价和荟萃分析，以验证酵母β-葡聚糖（BG）的消耗是否有利于肥胖和非肥胖啮齿动物的体重减轻。采用 PICO 策略，调查了接受酵母 BG 口服给药的啮齿动物（人群）（干预）与接受安慰剂的动物（对照）相比，评估体重变化（结局），并基于临床前研究（研究设计）。两位审查员搜索了六个数据库和灰色文献。我们遵循 PRISMA 2020 指南，并在 PROSPERO（CRD42021267788）上注册了方案。搜索返回了 2467 篇文章。有 30 篇文章被选中进行全文评估，根据入选标准仍有 7 项研究。根据肥胖（=4 项研究）和非肥胖动物（=4 项研究）分析 BG 摄入对体重的影响。尽管大多数肥胖啮齿动物的研究（75%）表明体重减轻（定性分析），但荟萃分析显示这并不显著（平均差异-1.35g-95%CI-5.14:2.45）。非肥胖动物也没有观察到效果。我们得出结论，酵母 BG 的摄入几乎不会影响肥胖和非肥胖动物的体重。
