Tossetta G, Avellini C, Licini C, Giannubilo S R, Castellucci M, Marzioni D
Polytechnic University of Marche, Department of Experimental and Clinical Medicine.
Eur J Histochem. 2016 Nov 21;60(4):2724. doi: 10.4081/ejh.2016.2724.
High temperature requirement A1 (HtrA1) is a secreted protease involved in placental development. Fibronectin (FN) is involved in important process such as wound healing, cell adhesion and spreading, growth, migration, and differentiation. The purpose of this study was to analyse the expression patterns of HtrA1 in relationship to FN and to the key growth zones of placenta such as mesenchymal villi as well as cell islands and cell columns. We demonstrated that FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation.
高温需求蛋白A1（HtrA1）是一种参与胎盘发育的分泌型蛋白酶。纤连蛋白（FN）参与诸如伤口愈合、细胞黏附与铺展、生长、迁移和分化等重要过程。本研究的目的是分析HtrA1与FN以及胎盘关键生长区域（如间充质绒毛以及细胞岛和细胞柱）相关的表达模式。我们证明，FN和HtrA1定位于胎盘关键生长区域，提示其在维持胎盘发育和分化相关分子间平衡中起关键作用。
