Yılmaz Fatma Hilal, Arı Yuca Sevil, Vatansev Hüsamettin, Cimbek Emine Ayça, Şen Yaşar, Yılmaz İsa, Akyürek Fikret, Arslan Derya, Çimen Derya, Yorulmaz Alaaddin
Selçuk University Faculty of Medicine, Department of Child Health and Diseases, Konya, Turkey, Phone: 0090332 224 39 88 E-mail:
J Clin Res Pediatr Endocrinol. 2017 Jun 1;9(2):118-123. doi: 10.4274/jcrpe.3961. Epub 2017 Jan 12.
This study aimed to measure the serum levels of heart-type fatty acid binding protein (H-FABP) in patients presenting with diabetic ketoacidosis (DKA) and diabetic ketosis (DK) and to determine its role in identifying early-period cardiac ischemia.
This prospective study included 35 patients diagnosed with DKA, 20 patients diagnosed with DK, and 20 control subjects. H-FABP, creatine kinase-MB (CK-MB), and troponin I levels were investigated at presentation in patients with DKA and DK and in the control group. H-FABP values were measured again after acidosis correction in the DKA patients.
No statistically significant differences were found with respect to troponin I and CK-MB within the groups. The H-FABP values of DKA patients at presentation were found to be significantly higher than those of DK patients and the control group (p=0.015). The H-FABP value of the DKA group was also found to be significantly higher than the value at hour 36 after acidosis correction (p=0.0001).
We would like to propose H-FABP as a potential marker for indicating myocardial ischemia.
本研究旨在测定糖尿病酮症酸中毒（DKA）和糖尿病酮症（DK）患者血清中心型脂肪酸结合蛋白（H-FABP）水平，并确定其在早期心肌缺血识别中的作用。
这项前瞻性研究纳入了35例诊断为DKA的患者、20例诊断为DK的患者以及20例对照受试者。对DKA和DK患者及对照组在就诊时检测H-FABP、肌酸激酶同工酶（CK-MB）和肌钙蛋白I水平。DKA患者酸中毒纠正后再次测定H-FABP值。
各组间肌钙蛋白I和CK-MB无统计学显著差异。发现DKA患者就诊时的H-FABP值显著高于DK患者和对照组（p = 0.015）。还发现DKA组的H-FABP值显著高于酸中毒纠正后36小时的值（p = 0.0001）。
我们建议将H-FABP作为指示心肌缺血的潜在标志物。
