Lee Ji-Woong, Morales Esteban, Sharifipour Farideh, Amini Navid, Yu Fei, Afifi Abdelmonem A, Coleman Anne L, Caprioli Joseph, Nouri-Mahdavi Kouros
Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Department of Ophthalmology, Pusan National University College of Medicine, Busan, South Korea.
Br J Ophthalmol. 2017 Aug;101(8):1052-1058. doi: 10.1136/bjophthalmol-2016-309208. Epub 2017 Jan 11.
To explore the correlation of local macular ganglion cell/inner plexiform layer (GC/IPL) thickness measurements with sensitivity at individual test locations on the central 10-2 visual fields (VFs) in patients with glaucoma.
One hundred thirty-seven eyes of 125 patients with spectral domain optical coherence tomography (OCT) and 10-2 VFs were included. The exported thickness matrices (200×200) of GC/IPL measurements were centred on the fovea. Total deviation values at each test location were correlated with the 20 000 GC/IPL thickness measurements in the corresponding inferior or superior hemiretina, and areas of highest correlation were plotted. Macular structure-function relationships were also examined between six wedge-shaped GC/IPL sectors and the corresponding VF clusters. A multivariate model was built to identify the 10-2 VF test locations associated with each GC/IPL sector thickness.
Average mean deviation on 10-2 VFs was -9.2±6.1 dB. The 10-2 VF test points demonstrated correlations with GC/IPL thickness in localised arcuate patterns mostly limited within the central 4.8×4.0 mm measurement ellipse (ρ=0.43-0.74, p<0.05 for all). Twenty-one test points of the 10-2 VF were the best predictors of sectoral GC/IPL thickness. Sectoral VF-OCT correlations were high (ρ=0.53-0.66, p<0.001) and did not significantly change after adjusting for retinal GC displacement (p>0.05).
Macular OCT/VF relationships have localised arcuate characteristics in the central region of the macula. Given the overlapping nature of structure-function relationships, a smaller number of VF test locations may be used to summarise macular functional damage.
NCT01742819.
探讨青光眼患者中央10-2视野（VF）中各个检测位点的黄斑神经节细胞/内丛状层（GC/IPL）厚度测量值与敏感度之间的相关性。
纳入125例患者的137只眼，这些患者均接受了光谱域光学相干断层扫描（OCT）和10-2视野检查。导出的GC/IPL测量厚度矩阵（200×200）以黄斑中心凹为中心。每个检测位点的总偏差值与相应下半视网膜或上半视网膜中20000个GC/IPL厚度测量值进行相关性分析，并绘制出相关性最高的区域。还对六个楔形GC/IPL扇形区与相应的视野簇之间的黄斑结构-功能关系进行了研究。建立多变量模型以确定与每个GC/IPL扇形区厚度相关的10-2视野检测位点。
10-2视野的平均平均偏差为-9.2±6.1dB。10-2视野检测点与GC/IPL厚度呈局限性弓形模式相关，大多局限于中央4.8×4.0mm测量椭圆内（ρ=0.43-0.74，所有p<0.05）。10-2视野的21个检测点是扇形GC/IPL厚度的最佳预测指标。扇形视野-OCT相关性较高（ρ=0.53-0.66，p<0.001），在调整视网膜GC移位后无显著变化（p>0.05）。
黄斑OCT/视野关系在黄斑中心区域具有局限性弓形特征。鉴于结构-功能关系的重叠性质，可使用较少数量的视野检测位点来概括黄斑功能损害。
NCT01742819。
