Mozaffari Hamid Reza, Sharifi Roohollah, Sadeghi Masoud
Department of Oral Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Acta Inform Med. 2016 Dec;24(6):390-393. doi: 10.5455/aim.2016.24.390-393.
Oral lichen planus (OLP) is associated with various other systemic conditions such as hypertension, diabetes mellitus (DM). This study evaluated the prevalence of OLP in DM patients compared with non-diabetic control subjects in a meta-analysis study.
In this study from January 1973 to August 2016, we searched the studies in Web of Science, Medline/PubMed, Scopus, Science direct, SID (Scientific Information Database), Cochrane and Embase databases. Strategy search was the Medical Subject Heading (MeSH) term oral lichen planus or oral mucosa combined with diabetes in PubMed and this search in other databases. Heterogeneity between estimates was evaluated by the Q and I statistic. Also, publication bias was assessed through funnel plot analysis with the Kendall's and Egger's tests.
From 831 studies were identified with different search strategies, 11 studies met the criteria to be included in meta-analysis (11 case-control studies). The overall prevalence of OLP in 11 studies with 4937 DM patients and 3698 control subjectswas 1.5% and 0.75%, respectively. In this meta-analysis, the OR in prevalence of OLP in DM patients compared with control subjects was 1.584 (95%CI1.013-2.477; P=0.044) with a low level of heterogeneity (I = 0%) that the result showed the prevalence of OLP in DM patients is significantly more than control subjects.
This meta-analysis study showed an association between OLP with DM, whereas this association was no significant in previous studies, it was probably because different selecting of age, sex, type of DM, medications and criteria. Totally, the meta-analysis showed the risk of OLP in DM was higher compared with control subjects.
口腔扁平苔藓（OLP）与多种其他全身性疾病相关，如高血压、糖尿病（DM）。本荟萃分析研究评估了糖尿病患者中OLP的患病率，并与非糖尿病对照受试者进行比较。
在本研究中，我们检索了1973年1月至2016年8月期间Web of Science、Medline/PubMed、Scopus、Science direct、SID（科学信息数据库）、Cochrane和Embase数据库中的研究。检索策略为在PubMed中使用医学主题词（MeSH）“口腔扁平苔藓”或“口腔黏膜”与“糖尿病”组合进行检索，并在其他数据库中进行类似检索。通过Q和I统计量评估估计值之间的异质性。此外，通过Kendall检验和Egger检验的漏斗图分析评估发表偏倚。
通过不同检索策略共识别出831项研究，其中11项研究符合纳入荟萃分析的标准（11项病例对照研究）。11项研究中，4937例糖尿病患者和3698例对照受试者中OLP的总体患病率分别为1.5%和0.75%。在本荟萃分析中，糖尿病患者与对照受试者相比，OLP患病率的OR为1.584（95%CI 1.013 - 2.477；P = 0.044），异质性水平较低（I = 0%），结果表明糖尿病患者中OLP的患病率显著高于对照受试者。
本荟萃分析研究表明OLP与糖尿病之间存在关联，而在先前的研究中这种关联并不显著，这可能是由于年龄、性别、糖尿病类型、药物和标准的选择不同所致。总体而言，荟萃分析表明糖尿病患者发生OLP的风险高于对照受试者。
