Department of Oral Pathology and Medicine, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia.
Diabetes Res Clin Pract. 2010 Sep;89(3):320-6. doi: 10.1016/j.diabres.2010.04.016. Epub 2010 May 20.
This study was aimed to determine the prevalence of oral mucosal lesions (OML) in patients with diabetes mellitus (DM) and non-diabetic subjects without any oral habits and to investigate the association of DM with oral precancerous lesions.
This cross-sectional study involved 420 diabetic and 420 non-diabetic control subjects without any oral habits. Detailed oral examination was performed based on international criteria.
A significantly greater proportion of subjects with DM (45%) had one or more OML in comparison to non-diabetics (38.3%). Patients with DM showed a significantly greater prevalence of geographic tongue, denture stomatitis and angular cheilitis than non-diabetics (p<0.05). The results also showed an association between occurrence of one or more OML and metabolic control of diabetic patients (p<0.05). For precancerous lesions, lichen planus was found in two diabetic patients while none of controls had any precancerous lesion (p>0.05).
Prevalence of OML was significantly higher in diabetic patients than non-diabetics and this prevalence was associated with the metabolic control of the patients. However, no association was observed between DM and oral precancerous lesions.
本研究旨在确定糖尿病（DM）患者和无任何口腔习惯的非糖尿病患者口腔黏膜病变（OML）的患病率，并探讨 DM 与口腔癌前病变的关系。
本横断面研究纳入了 420 例糖尿病患者和 420 例非糖尿病对照者，他们均无任何口腔习惯。根据国际标准进行了详细的口腔检查。
与非糖尿病患者（38.3%）相比，DM 患者（45%）有一个或多个 OML 的比例显著更高。DM 患者的地图舌、义齿性口炎和口角炎的患病率明显高于非糖尿病患者（p<0.05）。结果还表明，一个或多个 OML 的发生与糖尿病患者的代谢控制之间存在关联（p<0.05）。对于癌前病变，两名糖尿病患者患有扁平苔藓，而对照组中无一例存在任何癌前病变（p>0.05）。
与非糖尿病患者相比，DM 患者 OML 的患病率明显更高，且这种患病率与患者的代谢控制有关。然而，DM 与口腔癌前病变之间未观察到相关性。
