Exploratory Factor Analysis for Validating Traditional Chinese Syndrome Patterns of Chronic Atrophic Gastritis.

Traditional Chinese medicine (TCM) has long been used to treat chronic atrophic gastritis (CAG). The aim of the present study was to evaluate the TCM syndrome characteristics of CAG and its core pathogenesis so as to promote optimization of treatment strategies. This study was based on a participant survey conducted in 4 hospitals in China. Patients diagnosed with CAG were recruited by simple random sampling. Exploratory factor analysis (EFA) was conducted on syndrome extraction. Common factors extracted were assigned to six syndrome patterns: deficiency, stagnation, blood stasis, phlegm turbidity, heat, and deficiency. Distribution frequency of all syndrome patterns showed that deficiency, stagnation, blood stasis, phlegm turbidity, and heat excess were higher (76.7%-84.2%) compared with deficiency (42.5%). Distribution of main syndrome patterns showed that frequencies of deficiency, stagnation, phlegm turbidity, heat, and deficiency were higher (15.8%-20.8%) compared with blood stasis (8.3%). The core pathogenesis of CAG is combination of deficiency, stagnation, blood stasis, phlegm turbidity, heat, and deficiency. Therefore, treatment strategy of herbal prescriptions for CAG should include herbs that regulate , activate blood, resolve turbidity, clear heat, remove toxin, and warm yang.