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IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression.IQGAP1和IQGAP3在正常表皮稳态和肿瘤进展中分别发挥着至关重要的作用。
J Invest Dermatol. 2015 Sep;135(9):2258-2265. doi: 10.1038/jid.2015.140. Epub 2015 Apr 7.
2
Global cancer statistics, 2012.全球癌症统计数据，2012 年。
CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4.
3
Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.IQGAP家族蛋白参与哺乳动物细胞胞质分裂的调控。
Genes Cells. 2014 Nov;19(11):803-20. doi: 10.1111/gtc.12179. Epub 2014 Sep 17.
4
IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells.IQGAP3促进表皮生长因子受体-细胞外信号调节激酶（EGFR-ERK）信号传导以及肺癌细胞的生长和转移。
PLoS One. 2014 May 21;9(5):e97578. doi: 10.1371/journal.pone.0097578. eCollection 2014.
5
Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers.不同存档人类癌症样本中长链非编码RNA和新转录区域的转录组分析
Genome Biol. 2012 Aug 28;13(8):R75. doi: 10.1186/gb-2012-13-8-r75.
6
IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.IQGAP2，一种前列腺肿瘤发生的候选肿瘤抑制因子。
Biochim Biophys Acta. 2012 Jun;1822(6):875-84. doi: 10.1016/j.bbadis.2012.02.019. Epub 2012 Mar 2.
7
DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.DPEP1 抑制肿瘤细胞侵袭性，增强化疗敏感性，并预测胰腺导管腺癌的临床预后。
PLoS One. 2012;7(2):e31507. doi: 10.1371/journal.pone.0031507. Epub 2012 Feb 20.
8
IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma.IQGAP1 和 IQGAP2 在肝癌中相互改变。
BMC Gastroenterol. 2010 Oct 26;10:125. doi: 10.1186/1471-230X-10-125.
9
IQGAP1 plays an important role in the invasiveness of thyroid cancer.IQGAP1 在甲状腺癌的侵袭中发挥重要作用。
Clin Cancer Res. 2010 Dec 15;16(24):6009-18. doi: 10.1158/1078-0432.CCR-10-1627. Epub 2010 Oct 19.
10
Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin.乳腺癌细胞对赫赛汀耐药时表皮生长因子受体 erbB2、erbB3 和胰岛素样生长因子-i 受体的异三聚体化。
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IQGAP3在人胰腺癌中的过表达及生物学功能

Overexpression and biological function of IQGAP3 in human pancreatic cancer.

作者信息

Xu Weihong, Xu Bin, Yao Yiting, Yu Xiaoling, Cao Hua, Zhang Jun, Liu Jie, Sheng Huiming

机构信息

Department of Clinical Laboratory of Tongren Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China.

Institute of Digestive Diseases of Huashan Hospital, Fudan University Shanghai, China.

出版信息

Am J Transl Res. 2016 Dec 15;8(12):5421-5432. eCollection 2016.

PMID:28078013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5209493/
Abstract

IQGAP3 (IQ motif containing GTPase activating protein3) belongs to IQGAP family. Recent studies have investigated that IQGAP3 was overexpressed in several tumor tissues. This study was designed to explore the expression and role of IQGAP3 in pancreatic cancer, a highly lethal disease. IQGAP3 mRNA expression was significantly increased in pancreatic cancer tissues, compared with non-cancerous tissues. Moreover, its expression was strongly associated with tumor size, differentiation, lymph node metastasis and patients' overall survival. Gene set enrichment analysis (GSEA) on The Cancer Genome Atlas (TCGA) dataset showed that cell apoptosis, metastasis and Cdc42 pathways were strongly associated with IQGAP3 expression in pancreatic cancer patients. Knocking down of IQGAP3 in two pancreatic cancer cell lines with high level of IQGAP3 (BXPC-3 and SW1990) significantly inhibited cell proliferation, migration and invasion, and induced cell apoptosis. Moreover, silencing of IQGAP3 also affected the expression of cell apoptosis-, metastasis- and Cdc42 pathway-related proteins. Cdc42 knockdown had similar inhibitory effects on the cellular behavior of BXPC-3 cells. In conclusion, IQGAP3 may act as an oncogene in pancreatic cancer through regulating Cdc42 expression. Our data suggest IQGAP3 might be a novel diagnostic marker and therapeutic target for this cancer.

摘要

IQGAP3（含IQ模体的GTP酶激活蛋白3）属于IQGAP家族。近期研究发现IQGAP3在多种肿瘤组织中过表达。本研究旨在探讨IQGAP3在胰腺癌（一种高致死性疾病）中的表达及作用。与癌旁组织相比，胰腺癌组织中IQGAP3 mRNA表达显著增加。此外，其表达与肿瘤大小、分化程度、淋巴结转移及患者总生存期密切相关。对癌症基因组图谱（TCGA）数据集进行基因集富集分析（GSEA）表明，细胞凋亡、转移和Cdc42信号通路与胰腺癌患者的IQGAP3表达密切相关。在两个IQGAP3高水平表达的胰腺癌细胞系（BXPC-3和SW1990）中敲低IQGAP3，显著抑制细胞增殖、迁移和侵袭，并诱导细胞凋亡。此外，沉默IQGAP3也影响细胞凋亡、转移和Cdc42信号通路相关蛋白的表达。敲低Cdc42对BXPC-3细胞的细胞行为有类似的抑制作用。总之，IQGAP3可能通过调节Cdc42表达在胰腺癌中发挥癌基因作用。我们的数据表明IQGAP3可能是这种癌症的一种新型诊断标志物和治疗靶点。