依托咪酯和丙泊酚对肺腺癌患者免疫功能的影响。
Effects of etomidate and propofol on immune function in patients with lung adenocarcinoma.
作者信息
Liu Jiapeng, Dong Wei, Wang Tao, Liu Liang, Zhan Long, Shi Yifei, Han Jiange
机构信息
Department of Anesthesiology, Tianjin Chest Hospital Tianjin 300222, P R China.
出版信息
Am J Transl Res. 2016 Dec 15;8(12):5748-5755. eCollection 2016.
Abstract
OBJECTIVE
To investigate the effects of etomidate and propofol on immune function in patients with lung adenocarcinoma.
METHODS
Sixty patients who were scheduled for lung cancer surgery under general anesthesia were studied. The patients were randomly divided into an etomidate total intravenous anesthesia group (group E) and a propofol total intravenous anesthesia group (group P), with 30 cases in each group.
RESULTS
Within group comparison: The percentage of CD4+ in the two groups was significantly reduced at 24 hours post-operation (T) compared with the percentage before surgery, whereas the percentage of CD8+ was higher at T. Between group comparison: The CD4+ percentage of group E was higher than that of group P ( < 0.05) at T, whereas the CD8+ percentage was lower than that of group P ( < 0.05) at T.
CONCLUSION
Using etomidate for anesthesia has less of an effect on immune function in patients with lung adenocarcinoma.
摘要
目的
探讨依托咪酯和丙泊酚对肺腺癌患者免疫功能的影响。
方法
选取60例拟行全身麻醉下肺癌手术的患者进行研究。将患者随机分为依托咪酯全凭静脉麻醉组（E组）和丙泊酚全凭静脉麻醉组（P组），每组30例。
结果
组内比较：与术前相比，两组术后24小时（T）CD4+百分比显著降低，而T时CD8+百分比升高。组间比较：T时E组CD4+百分比高于P组（<0.05），而T时CD8+百分比低于P组（<0.05）。
结论
使用依托咪酯进行麻醉对肺腺癌患者免疫功能的影响较小。
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