Department of Anesthesiology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Suzhou Medical College of Soochow University, Suzhou, China.
Front Immunol. 2024 Sep 4;15:1441020. doi: 10.3389/fimmu.2024.1441020. eCollection 2024.
This review comprehensively examines the impact of anesthesia and surgical interventions on the immune function of cancer patients postoperatively. Recent studies have shown that surgery and its accompanying anesthesia management can significantly influence immune function in cancer patients, potentially affecting their prognosis. This review synthesizes clinical studies and basic research to summarize the specific effects of anesthesia methods, drugs, postoperative analgesia, intraoperative transfusion, surgical techniques, and trauma extent on the immune function of cancer patients post-surgery. Additionally, this review discusses optimization strategies based on current research, aiming to refine anesthesia and surgical management to maximize the preservation and enhancement of postoperative immune function in cancer patients, with the potential to improve clinical outcomes.
这篇综述全面考察了麻醉和手术干预对癌症患者术后免疫功能的影响。最近的研究表明，手术及其伴随的麻醉管理会显著影响癌症患者的免疫功能，从而可能影响他们的预后。该综述综合了临床研究和基础研究，总结了麻醉方法、药物、术后镇痛、术中输血、手术技术和创伤程度对癌症患者术后免疫功能的具体影响。此外，该综述还讨论了基于当前研究的优化策略，旨在改进麻醉和手术管理，以最大限度地保留和增强癌症患者术后的免疫功能，从而有可能改善临床结局。
