反复轻度创伤性脑损伤会导致外侧隔区和海马体出现局灶性反应。
Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus.
作者信息
Acabchuk Rebecca, Briggs Denise I, Angoa-Pérez Mariana, Powers Meghan, Wolferz Richard, Soloway Melanie, Stern Mai, Talbot Lillian R, Kuhn Donald M, Conover Joanne C
机构信息
Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
John D Dingell VA Medical Center and Wayne State University School of Medicine, Detroit, MI 48201, USA.
出版信息
Concussion. 2016 Dec;1(3). doi: 10.2217/cnc-2015-0001. Epub 2016 May 25.
AIM
To advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces.
MATERIALS & METHODS: A modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits delivered over 15 days). Regional investigations of forebrain and midbrain histological alterations were performed at three post-injury time points (immediate, 2 weeks and 6 weeks).
RESULTS
The rmTBI-short protocol generated an immediate, localized microglial and astroglial response in the dorsolateral septum and hippocampus, with the astroglial response persisting in the dorsolateral septum. The rmTBI-long protocol showed only a transitory astroglial response in the dorsolateral septum.
CONCLUSION
Our results indicate that the lateral septum and hippocampus are particularly vulnerable regions in rmTBI, possibly contributing to memory and emotional impairments associated with repeated concussions.
目的
为了加深我们对反复轻度创伤性脑损伤（rmTBI）的区域和时间细胞反应的理解，我们使用了一种包含加速、减速和旋转力的rmTBI小鼠模型。
材料与方法
采用改良的重物下落法比较两种损伤间隔，即rmTBI-短（3天内进行5次撞击）和rmTBI-长（15天内进行5次撞击）。在损伤后的三个时间点（即刻、2周和6周）对前脑和中脑组织学改变进行区域研究。
结果
rmTBI-短方案在背外侧隔区和海马体中产生了即刻的、局部的小胶质细胞和星形胶质细胞反应，星形胶质细胞反应在背外侧隔区持续存在。rmTBI-长方案在背外侧隔区仅显示出短暂的星形胶质细胞反应。
结论
我们的结果表明，外侧隔区和海马体是rmTBI中特别易损的区域，可能导致与反复脑震荡相关的记忆和情绪障碍。
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