Raberahona Mihaja, Rakotoarivelo Rivonirina A, Randriamampionona Njary, Rakotomalala Angelot F, Razafinambinintsoa Tiana, Bénet Thomas, Vanhems Philippe, Randria Mamy J D D, Cornet Muriel, Rakoto-Andrianarivelo Mala
Service des Maladies Infectieuses, HU Joseph Raseta de Befelatanana, Antananarivo, Madagascar.
Service des Maladies Infectieuses, CHU Tambohobe, Fianarantsoa, Madagascar.
Case Rep Infect Dis. 2016;2016:3492504. doi: 10.1155/2016/3492504. Epub 2016 Dec 18.
Cryptococcal meningoencephalitis is considered rare in HIV-negative individuals. In Madagascar, the epidemiology of cryptococcosis has not yet been well described, neither in immunocompetent nor in immunocompromised patients. We report here the first Malagasy detailed case of cryptococcal meningoencephalitis in a non-HIV immunocompromised adult patient carrying a low fluconazole susceptibility isolate. We emphasize the importance of early and accurate diagnosis to meet the challenges of managing cryptococcosis in developing countries.
隐球菌性脑膜脑炎在HIV阴性个体中被认为较为罕见。在马达加斯加，无论是免疫功能正常还是免疫功能低下的患者，隐球菌病的流行病学情况都尚未得到充分描述。我们在此报告马达加斯加首例非HIV免疫功能低下成年患者的隐球菌性脑膜脑炎详细病例，该患者携带对氟康唑敏感性较低的分离株。我们强调早期准确诊断对于应对发展中国家隐球菌病管理挑战的重要性。
