Senadim Songul, Alpaydin Baslo Sezin, Tekin Güveli Betül, Dedei Daryan Metin, Kantaroglu Elif, Ozturk Oya, Atakli Dilek
Department of Neurology, Bakirkoy Research and Training Hospital for Psychiatry, Neurology, Neurosurgery, Istanbul, Turkey.
Neurol Sci. 2016 Jul;37(7):1145-8. doi: 10.1007/s10072-016-2550-9. Epub 2016 Mar 29.
Cryptococcal meningoencephalitis (CM) is a serious central nervous system infection caused by Cryptococcus neoformans, seen mostly in immunocompromised hosts and less in immunocompetent patients. The vast majority of cryptococcosis cases are seen as human immunodeficiency virus infections with advanced immunosuppression. Meningitis and meningoencephalitis are the most common clinical manifestations. Nevertheless, immunocompetent patients with CM are rarely reported. Cerebral venous sinus thrombosis is a rare complication of CM. Here, we report an immunocompetent patient with CM from a non-endemic area, who presented with an acute onset and atypical symptoms associated with cerebral venous thrombosis.
隐球菌性脑膜脑炎（CM）是由新型隐球菌引起的一种严重的中枢神经系统感染，多见于免疫功能低下的宿主，在免疫功能正常的患者中较少见。绝大多数隐球菌病病例见于伴有严重免疫抑制的人类免疫缺陷病毒感染。脑膜炎和脑膜脑炎是最常见的临床表现。然而，免疫功能正常的CM患者很少被报道。脑静脉窦血栓形成是CM的一种罕见并发症。在此，我们报告一例来自非流行地区的免疫功能正常的CM患者，该患者急性起病，伴有与脑静脉血栓形成相关的非典型症状。
