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绝经后潮热大鼠模型中[提取物名称]水提取物的作用 。（你提供的原文中“of”后面缺少具体内容）

Effects of Aqueous Extracts of in Rat Models for Postmenopausal Hot Flush.

作者信息

Lee Gyuok, Choi Chul-Yung, Jun Woojin

机构信息

Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Korea; Jeollanamdo Institute of Natural Resources Research, Jeonnam 59338, Korea.

Jeollanamdo Institute of Natural Resources Research, Jeonnam 59338, Korea.

出版信息

Prev Nutr Food Sci. 2016 Dec;21(4):373-377. doi: 10.3746/pnf.2016.21.4.373. Epub 2016 Dec 31.

DOI:10.3746/pnf.2016.21.4.373
PMID:28078261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5216890/
Abstract

Menopausal hot flushes (HFs), which manifest as a transient increase in skin temperature, occur most frequently in postmenopausal women, and sometimes negatively influence daily life. We investigated the effect of an aqueous extract of (CWW) in a rat model of menopausal HFs, where tail skin temperature (TST) is increased after the rapid estrogen decline induced by ovariectomy. Ten-week-old female rats were ovariectomized and treated with CWW for 1 week. We measured TST and rectal temperatures (RT) and investigated serum estradiol. The TST in ovariectomized (OVX) rats was significantly elevated after ovariectomy compared with control rats, whereas the RT in OVX rats was not elevated. Administration of CWW (200 mg/kg/d for 7 days, p.o.) significantly improved the skin temperature increase in OVX rats. The lower level of serum estradiol in OVX rats was significantly increased by supplying E2, but it was not affected by CWW. The present study indicates a need for future research involving treatment with high concentrations of and measurement over 24 h.

摘要

更年期潮热（HFs）表现为皮肤温度短暂升高，在绝经后女性中最为常见，有时会对日常生活产生负面影响。我们在更年期潮热的大鼠模型中研究了[提取物名称未给出]水提取物（CWW）的作用，在该模型中，卵巢切除诱导雌激素快速下降后，尾皮肤温度（TST）会升高。将10周龄雌性大鼠进行卵巢切除，并给予CWW治疗1周。我们测量了TST和直肠温度（RT），并检测了血清雌二醇。与对照大鼠相比，卵巢切除（OVX）大鼠在卵巢切除后TST显著升高，而OVX大鼠的RT未升高。给予CWW（200mg/kg/d，连续7天，口服）可显著改善OVX大鼠皮肤温度的升高。通过补充E2可使OVX大鼠较低水平的血清雌二醇显著升高，但CWW对其无影响。本研究表明，未来需要开展涉及高浓度[提取物名称未给出]治疗及24小时测量的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c2/5216890/3179cb3be9dc/pnfs-21-373f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c2/5216890/f72b6944b36d/pnfs-21-373f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c2/5216890/4c1aad61c421/pnfs-21-373f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c2/5216890/3179cb3be9dc/pnfs-21-373f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c2/5216890/f72b6944b36d/pnfs-21-373f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c2/5216890/4c1aad61c421/pnfs-21-373f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c2/5216890/3179cb3be9dc/pnfs-21-373f3.jpg

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