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[专科领域痛风性关节炎诊断与治疗的循证推荐:德国风湿病学会与德国医学专业协会共同发布的S2e指南]

[Evidence-based recommendations for diagnostics and treatment of gouty arthritis in the specialist sector : S2e guidelines of the German Society of Rheumatology in cooperation with the AWMF].

作者信息

Kiltz U, Alten R, Fleck M, Krüger K, Manger B, Müller-Ladner U, Nüsslein H, Reuss-Borst M, Schwarting A, Schulze-Koops H, Tausche A K, Braun J

机构信息

Rheumazentrum Ruhrgebiet, Claudiusstr. 45, 44649, Herne, Deutschland.

Rheumatologie, Klinische Immunologie, Osteologie, Physikalische Therapie und Sportmedizin, Schlosspark-Klinik, Berlin, Deutschland.

出版信息

Z Rheumatol. 2017 Mar;76(2):118-124. doi: 10.1007/s00393-016-0249-1.

DOI:10.1007/s00393-016-0249-1
PMID:28078432
Abstract

Due to the increasing prevalence of gout, particularly in old age, the disease is becoming of increasing importance in Germany. Gout is one of the most common forms of recurrent inflammatory arthritis and is induced by the deposition of monosodium urate crystals in synovial fluid and other tissues. The principal goals of therapy in chronic gout are the symptomatic treatment of the acute joint inflammation and the causal treatment of the underlying metabolic cause, the hyperuricemia. Only a consistent and permanent reduction of the serum uric acid level ultimately results in an efficient avoidance of further gout attacks and therefore the prevention of structural damage. Due to an often inadequate treatment of gout, the target of healing the disease is often not achieved. A correct and timely diagnosis and adequate assessment of comorbidities associated with gout are, however, of substantial importance for patient and physician to achieve remission of the disease. In order to create a solid basis for a timely and effective treatment of affected patients, in 2016 the German Society of Rheumatology (DGRh) initiated the development of S2e guidelines on gouty arthritis for specialists. This article summarizes these S2e guidelines on the management of gouty arthritis in the specialist sector.

摘要

由于痛风的患病率不断上升,尤其是在老年人群中,该病在德国正变得越来越重要。痛风是复发性炎症性关节炎最常见的形式之一,由尿酸钠晶体在滑液和其他组织中的沉积所致。慢性痛风治疗的主要目标是对急性关节炎症进行对症治疗以及对潜在的代谢病因即高尿酸血症进行病因治疗。只有持续且永久性地降低血清尿酸水平,最终才能有效避免进一步的痛风发作,从而预防结构损伤。由于痛风治疗往往不充分,治愈该病的目标常常无法实现。然而,正确及时的诊断以及对与痛风相关的合并症进行充分评估,对于患者和医生实现疾病缓解至关重要。为了为及时有效治疗受影响患者奠定坚实基础,2016年德国风湿病学会(DGRh)启动了针对专科医生的痛风性关节炎S2e指南的制定工作。本文总结了专科领域痛风性关节炎管理的这些S2e指南。

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本文引用的文献

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[Full version of the S2e guidelines on gouty arthritis : Evidence-based guidelines of the German Society of Rheumatology (DGRh)].[痛风性关节炎S2e指南完整版:德国风湿病学会(DGRh)循证指南]
Z Rheumatol. 2016 Aug;75 Suppl 2:11-60. doi: 10.1007/s00393-016-0147-6.
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Arthritis Care Res (Hoboken). 2012 Oct;64(10):1447-61. doi: 10.1002/acr.21773.
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