通过 Cu 催化和可见光促进的途径，串联自由基环化构建 1-二氟烷基异喹啉。
Tandem radical cyclization for the construction of 1-difluoroalkylated isoquinolines via Cu catalyzed and visible light-promoted pathways.
机构信息
Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen 518055, China.
出版信息
Org Biomol Chem. 2018 Mar 14;16(11):1812-1815. doi: 10.1039/c8ob00232k.
PMID:29473083
Abstract
A Cu/Bpin system promoted cyclization for the synthesis of 1-difluoroalkylated isoquinolines with vinyl isocyanides and bromodifluoroacetic derivatives in moderate to good yields was reported. This method provided a mild and efficient pathway for the construction of diverse 1-difluoroalkylated isoquinolines via a proposed tandem radical cyclization process.
摘要
报道了一种 Cu/Bpin 体系促进的环化反应，用于合成 1-二氟烷基化异喹啉，该反应以乙烯基异氰化物和溴代二氟乙酸衍生物为原料，产率中等至良好。该方法通过串联自由基环化过程，为构建各种 1-二氟烷基化异喹啉提供了一种温和高效的途径。
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