Department of Neurology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China.
Department of Neurology, The Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China.
Sci Rep. 2017 Jan 12;7:40469. doi: 10.1038/srep40469.
There is convincing evidence that abnormalities of regional brain function exist in Parkinson's disease (PD). However, many resting-state functional magnetic resonance imaging (rs-fMRI) studies using amplitude of low-frequency fluctuations (ALFF) have reported inconsistent results about regional spontaneous neuronal activity in PD. Therefore, we conducted a comprehensive meta-analysis using the Seed-based d Mapping and several complementary analyses. We searched PubMed, Embase, and Web of Science databases for eligible whole-brain rs-fMRI studies that measured ALFF differences between patients with PD and healthy controls published from January 1st, 2000 until June 24, 2016. Eleven studies reporting 14 comparisons, comparing 421 patients and 381 healthy controls, were included. The most consistent and replicable findings in patients with PD compared with healthy controls were identified, including the decreased ALFFs in the bilateral supplementary motor areas, left putamen, left premotor cortex, and left inferior parietal gyrus, and increased ALFFs in the right inferior parietal gyrus. The altered ALFFs in these brain regions are related to motor deficits and compensation in PD, which contribute to understanding its neurobiological underpinnings and could serve as specific regions of interest for further studies.
有确凿的证据表明帕金森病（PD）存在区域性脑功能异常。然而，许多使用低频波动振幅（ALFF）的静息态功能磁共振成像（rs-fMRI）研究报告了 PD 患者局部自发性神经元活动的结果不一致。因此，我们使用基于种子的映射和几种补充分析进行了综合荟萃分析。我们在 PubMed、Embase 和 Web of Science 数据库中搜索了从 2000 年 1 月 1 日至 2016 年 6 月 24 日发表的比较 PD 患者和健康对照组之间 ALFF 差异的全脑 rs-fMRI 研究。纳入了 11 项研究，报告了 14 项比较，比较了 421 名患者和 381 名健康对照组。确定了与健康对照组相比，PD 患者最一致和可重复的发现，包括双侧辅助运动区、左侧壳核、左侧运动前皮质和左侧顶下小叶的 ALFF 降低，以及右侧顶下小叶的 ALFF 增加。这些脑区的改变的 ALFF 与 PD 中的运动缺陷和代偿有关，有助于理解其神经生物学基础，并可作为进一步研究的特定感兴趣区域。
