Salz Helen K, Dawson Emily P, Heaney Jason D
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
Mol Reprod Dev. 2017 Mar;84(3):200-211. doi: 10.1002/mrd.22779.
Ovarian and testicular germ cell tumors of young adults are thought to arise from defects in germ cell development, but the molecular mechanisms underlying malignant transformation are poorly understood. In this review, we focus on the biology of germ cell tumor formation in the Drosophila ovary and the mouse testis, for which evidence supports common underlying mechanisms, such as blocking initiation into the differentiation pathway, impaired lineage progression, and sexual identity instability. We then discuss how these concepts inform our understanding of the disease in humans. Mol. Reprod. Dev. 84: 200-211, 2017. © 2017 Wiley Periodicals, Inc.
年轻成年人的卵巢和睾丸生殖细胞肿瘤被认为起源于生殖细胞发育缺陷，但恶性转化的分子机制尚不清楚。在这篇综述中，我们重点关注果蝇卵巢和小鼠睾丸中生殖细胞肿瘤形成的生物学，有证据支持其存在共同的潜在机制，如阻止进入分化途径、谱系进展受损和性身份不稳定。然后我们讨论这些概念如何增进我们对人类疾病的理解。《分子生殖与发育》84: 200 - 211, 2017。© 2017威利期刊公司。
