在大鼠中，5-羟色胺或多巴胺与利多卡因联合应用产生痛觉阻滞的协同作用。
Synergistic Effects of Serotonin or Dopamine Combined With Lidocaine at Producing Nociceptive Block in Rats.
机构信息
From the *Department of Physical Therapy and †Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University; and ‡Department of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan; §Department of General Surgery, Chi Mei Medical Center, Tainan and Liouying; ∥Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan; ¶Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Health Care, China Medical University, Taichung; and **Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
出版信息
Reg Anesth Pain Med. 2017 May/Jun;42(3):351-356. doi: 10.1097/AAP.0000000000000552.
BACKGROUND
The purpose of this experiment was to investigate the interactions of the local anesthetic lidocaine combined with an agent (serotonin or dopamine) as infiltrative anesthetics.
METHODS
Cutaneous analgesia was characterized by the blockade of the cutaneous trunci muscle reflex following 6 skin pinpricks on the rat back. Serotonin or dopamine at producing cutaneous analgesia in a dosage-dependent fashion was compared with lidocaine. Drug-drug interactions were calculated using the isobolographic analysis.
RESULTS
We revealed that serotonin, dopamine, and lidocaine provoked dose-related cutaneous analgesic effects. On the 50% effective dose basis, the rank of drugs' potency was found to be serotonin (1.70 [1.56-1.85] μmol) > lidocaine (5.18 [4.67-5.75] μmol) > dopamine (43.0 [40.9-45.2] μmol) (P < 0.01). At doses equivalent to their 25%, 50%, and 75% effective doses, serotonin or dopamine elicited a longer duration of action than lidocaine (P < 0.01) on producing cutaneous analgesia. Coadministration of serotonin or dopamine with lidocaine produced a synergistic effect.
CONCLUSIONS
The preclinical data showed that serotonin and dopamine produce dose-related cutaneous analgesic effects as an infiltrative anesthetic. Serotonin has a better potency with a much longer duration of action compared with lidocaine at provoking cutaneous analgesia. Serotonin or dopamine as an adjuvant increases the quality of lidocaine in cutaneous analgesia.
背景
本实验旨在研究局部麻醉药利多卡因与一种药物（血清素或多巴胺）联合作为浸润性麻醉剂的相互作用。
方法
通过在大鼠背部进行 6 次皮肤刺痛来描述皮肤横肌反射的阻断来表征皮肤镇痛。比较了血清素或多巴胺以剂量依赖性方式产生皮肤镇痛的作用与利多卡因。使用等立体分析计算药物-药物相互作用。
结果
我们发现血清素、多巴胺和利多卡因均引起剂量相关的皮肤镇痛作用。基于 50%有效剂量，发现药物效力的等级为血清素（1.70[1.56-1.85]μmol）>利多卡因（5.18[4.67-5.75]μmol）>多巴胺（43.0[40.9-45.2]μmol）（P<0.01）。在剂量相当于其 25%、50%和 75%有效剂量时，与利多卡因相比，血清素或多巴胺引起的皮肤镇痛作用持续时间更长（P<0.01）。血清素或多巴胺与利多卡因联合使用产生协同作用。
结论
临床前数据表明，血清素和多巴胺产生剂量相关的皮肤镇痛作用作为浸润性麻醉剂。与利多卡因相比，血清素在引起皮肤镇痛方面具有更好的效力和更长的作用持续时间。作为佐剂的血清素或多巴胺可提高利多卡因在皮肤镇痛中的质量。
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