Wu Wei-Jie, Wang Shan-Huan, Ling Wei, Geng Li-Jun, Zhang Xiao-Xi, Yu Lan, Chen Jun, Luo Jiang-Xi, Zhao Hai-Lu
aCenter for Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University bDepartment of Pathology, the Affiliated Hospital of Guilin Medical University cCollege of Basic Medical Sciences, Guilin Medical University, Guilin, China.
Medicine (Baltimore). 2017 Jan;96(2):e5838. doi: 10.1097/MD.0000000000005838.
Disturbance of oxygen-carbon dioxide homeostasis has an impact on cancer. Little is known about the effect of breath training on cancer patients. Here we report our 10-year experience with morning breathing exercises (MBE) in peer-support programs for cancer survivors.We performed a cohort study to investigate long-term surviving patients with lung cancer (LC) and nasopharyngeal cancer (NPC) who practiced MBE on a daily basis. End-tidal breath holding time (ETBHT) after MBE was measured to reflect improvement in alveolar O2 pressure and alveolar CO2 pressure capacity.Patients (female, 57) with a diagnosis of LC (90 patients) and NPC (32 patients) were included. Seventy-six of them were MBE trainees. Average survival years were higher in MBE trainees (9.8 ± 9.5) than nontrainees (3.3 ± 2.8). The 5-year survival rate was 56.6% for MBE trainees and 19.6% for nontrainees (RR = 5.371, 95% CI = 2.271-12.636, P < 0.001). Survival probability of the trainees further increased 17.9-fold for the 10-year survival rate. Compared with the nontrainees, the MBE trainees shows no significant differences in ETBHT (baseline, P = 0.795; 1-2 years, P = 0.301; 3-4 years, P = 0.059) at baseline and within the first 4 years. From the 5th year onwards, significant improvements were observed in ETBHT, aCO2%, PaCO2, and PaO2 (P = 0.028). In total, 18 trainees (40.9%) and 20 nontrainees (74.1%) developed new metastasis (RR = 0.315, 95% CI = 0.108-0.919, P = 0.031).MBE might benefit for the long-term survival in patients with LC and NPC due to improvement in hyperventilation.
氧-二氧化碳稳态紊乱对癌症有影响。关于呼吸训练对癌症患者的影响知之甚少。在此，我们报告我们在癌症幸存者同伴支持项目中进行10年晨呼吸练习（MBE）的经验。我们进行了一项队列研究，以调查每天进行MBE的肺癌（LC）和鼻咽癌（NPC）长期存活患者。测量MBE后的呼气末屏气时间（ETBHT），以反映肺泡氧分压和肺泡二氧化碳分压能力的改善。纳入了诊断为LC（90例患者）和NPC（32例患者）的患者（女性，57例）。其中76例为MBE受训者。MBE受训者的平均存活年数（9.8±9.5）高于非受训者（3.3±2.8）。MBE受训者的5年生存率为56.6%，非受训者为19.6%（RR = 5.371，95% CI = 2.271 - 12.636，P < 0.001）。受训者的10年生存率的生存概率进一步提高了17.9倍。与非受训者相比，MBE受训者在基线时和前4年内ETBHT无显著差异（基线时，P = 0.795；1 - 2年，P = 0.301；3 - 4年，P = 0.059）。从第5年起，观察到ETBHT、aCO2%、PaCO2和PaO2有显著改善（P = 0.028）。共有18名受训者（40.9%）和20名非受训者（74.1%）发生了新的转移（RR = 0.315，95% CI = 0.108 - 0.919，P = 0.031）。由于过度通气的改善，MBE可能有利于LC和NPC患者的长期生存。
