血清和玻璃体中nesfatin-1浓度与糖尿病视网膜病变的关系。
Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy.
作者信息
Dai Rongfeng, Deng Guohua, Sun Zhuo, Liu Zhinan, Qian Yu, Han Yan
机构信息
Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, China.
Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, China.
出版信息
J Clin Lab Anal. 2017 Sep;31(5). doi: 10.1002/jcla.22105. Epub 2017 Jan 12.
OBJECTIVE
Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR).
METHODS
This study was performed in a population of 189 diabetic patients and 48 control subjects. Diabetic patients were then divided into diabetic patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients.
RESULTS
Serum and vitreous nesfatin-1 concentrations were significantly lower in the diabetic patients than in the controls. NPDR patients had reduced vitreous nesfatin-1 concentrations compared with patients without DR. In addition, there were significantly lower serum and vitreous nesfatin-1 concentrations in PDR patients compared with the other three groups. Pearson correlation analysis showed that serum nesfatin-1 was negatively correlated with body mass index and fasting plasma glucose in diabetic patients.
CONCLUSION
Serum and vitreous nesfatin-1 concentrations were negatively correlated with DR.
目的
Nesfatin-1属于脂肪因子家族，是一种抗炎介质。我们进行这项研究以评估血清和玻璃体中Nesfatin-1浓度与糖尿病视网膜病变（DR）之间的关系。
方法
本研究纳入了189名糖尿病患者和48名对照受试者。然后将糖尿病患者分为无DR的糖尿病患者、非增殖性糖尿病视网膜病变（NPDR）患者和增殖性糖尿病视网膜病变（PDR）患者。
结果
糖尿病患者血清和玻璃体中Nesfatin-1浓度显著低于对照组。与无DR的患者相比，NPDR患者的玻璃体Nesfatin-1浓度降低。此外，与其他三组相比，PDR患者的血清和玻璃体Nesfatin-1浓度显著降低。Pearson相关性分析显示，糖尿病患者血清Nesfatin-1与体重指数和空腹血糖呈负相关。
结论
血清和玻璃体Nesfatin-1浓度与DR呈负相关。
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