Wan Wencui, Li Qiuming, Zhang Fengyan, Zheng Guangying, Lv Yong, Wan Guangming, Jin Xuemin
Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Dis Markers. 2015;2015:754312. doi: 10.1155/2015/754312. Epub 2015 Sep 3.
Omentin, a new discovered adipokine, is implicated to inhibit inflammation. Inflammation is one important mechanism of diabetic retinopathy (DR). The purpose of this work was to evaluate serum and vitreous concentrations of omentin-1 in patients with diabetic retinopathy (DR).
This study enrolled 204 diabetic patients (60 without DR, 49 with NPDR, and 95 with PDR) and 65 control subjects.
Serum and vitreous omentin-1 levels in PDR patients were markedly decreased compared with those in the other three groups. NPDR patients showed reduced vitreous omentin-1 compared with patients without DR. In addition, control subjects had significantly higher levels of serum and vitreous omentin-1 compared with diabetic patients without DR, NPDR patients, and PDR patients. In addition, serum/vitreous omentin-1 ratio was positively correlated with the development and severity of DR.
Serum and vitreous omentin-1 levels, as well as serum/vitreous omentin-1 ratio, are correlated with the presence and severity of DR.
网膜素是一种新发现的脂肪因子，被认为具有抗炎作用。炎症是糖尿病视网膜病变（DR）的一个重要机制。本研究旨在评估糖尿病视网膜病变（DR）患者血清和玻璃体中网膜素-1的浓度。
本研究纳入了204例糖尿病患者（60例无DR，49例有非增殖性糖尿病视网膜病变（NPDR），95例有增殖性糖尿病视网膜病变（PDR））和65例对照受试者。
与其他三组相比，PDR患者的血清和玻璃体网膜素-1水平显著降低。与无DR的患者相比，NPDR患者的玻璃体网膜素-1水平降低。此外，与无DR的糖尿病患者、NPDR患者和PDR患者相比，对照受试者的血清和玻璃体网膜素-1水平显著更高。此外，血清/玻璃体网膜素-1比值与DR的发生和严重程度呈正相关。
血清和玻璃体网膜素-1水平以及血清/玻璃体网膜素-1比值与DR的存在和严重程度相关。
