Song C W, Chelstrom L M, Levitt S H, Haumschild D J
University of Minnesota Medical School, Dept. of Therapeutic Radiology, Mpls. 55455.
Int J Radiat Oncol Biol Phys. 1989 Nov;17(5):1041-7. doi: 10.1016/0360-3016(89)90153-3.
The effects of local heating or cooling on skin microcirculation in volar aspect of human forearms was studied using laser Doppler flowmetry. When the skin was heated to 40 degrees C from a normal temperature of 32 degrees C, red cell flow (laser Doppler flow, blood flow) momentarily increased several fold and then temporarily decreased. The flow subsequently resumed a gradual increase reaching 10-15 times that of control in 30-40 min. When the skin temperature was returned to 32 degrees C after 60 min of heating, the blood flow momentarily declined but soon increased for several minutes before it began its major descent. When cooled from 32 degrees C to 5 degrees C, the flow momentarily decreased, but soon increased, surpassing the pre-cooling level. The flow began to decline when the cooling was prolonged for more than 15-20 min. The changes in flow corresponded well with the changes in number (volume) and speed of red cells. Laser Doppler flowmetry was found to be very useful for continuously monitoring microcirculatory blood flow in human skin.
采用激光多普勒血流仪研究了局部加热或冷却对人体前臂掌侧皮肤微循环的影响。当皮肤从32℃的正常温度加热至40℃时，红细胞血流（激光多普勒血流、血流量）瞬间增加数倍，随后暂时下降。随后血流逐渐恢复增加，在30 - 40分钟内达到对照值的10 - 15倍。加热60分钟后当皮肤温度恢复到32℃时，血流瞬间下降，但在开始大幅下降前几分钟内很快又增加。当从32℃冷却至5℃时，血流瞬间减少，但很快增加，超过冷却前水平。当冷却持续超过15 - 20分钟时血流开始下降。血流变化与红细胞数量（体积）和速度的变化非常吻合。发现激光多普勒血流仪对于连续监测人体皮肤微循环血流非常有用。
