Watson Megan K, Thurber Mary, Chinnadurai Sathya K
J Zoo Wildl Med. 2016 Dec;47(4):1019-1024. doi: 10.1638/2015-0190.1.
The objective of this study was to compare a traditional partially reversible medetomidine-ketamine sedation with a more reversible butorphanol-azaperone-medetomidine combination in Bennett's wallabies ( Macropus rufogriseus ) maintained in a zoological collection. Fourteen animals were divided into two treatment groups. Individuals in group 1 received an intramuscular (i.m.) injection of butorphanol (0.54 ± 0.05 mg/kg), azaperone (0.22 ± 0.02 mg/kg), and medetomidine (0.16 ± 0.02 mg/kg). Individuals in group 2 received an i.m. injection of ketamine (5.43 ±1.16 mg/kg) with medetomidine (0.05 ± 0.014 mg/kg). For group 1, sedation was reversed with atipamezole (0.81 ± 0.069 mg/kg i.m.) and naltrexone (1.08 ± 0.09 mg/kg i.m.). For group 2, sedation was reversed with atipamezole (0.27 ± 0.056 mg/kg i.m.). There were no significant differences between the groups in mean time to induction, time spent on gas anesthesia, or time to standing after reversal was administered. Animals in both groups required supplemental gas anesthesia to facilitate intubation. No adverse reactions or effects were noted with either protocol; however, the BAM protocol did not provide sufficient sedation for handling in all animals and may not be suitable for use in this species.
本研究的目的是比较传统的部分可逆性美托咪定 - 氯胺酮镇静方案与更具可逆性的布托啡诺 - 阿扎哌隆 - 美托咪定组合方案，用于动物园圈养的贝内特小袋鼠（赤褐大袋鼠）。14只动物被分为两个治疗组。第1组个体接受肌肉注射布托啡诺（0.54±0.05毫克/千克）、阿扎哌隆（0.22±0.02毫克/千克）和美托咪定（0.16±0.02毫克/千克）。第2组个体接受肌肉注射氯胺酮（5.43±1.16毫克/千克）和美托咪定（0.05±0.014毫克/千克）。对于第1组，使用阿替美唑（0.81±0.069毫克/千克，肌肉注射）和纳曲酮（1.08±0.09毫克/千克，肌肉注射）逆转镇静。对于第2组，使用阿替美唑（0.27±0.056毫克/千克，肌肉注射）逆转镇静。两组在诱导平均时间、气体麻醉时间或给予逆转药物后站立时间方面没有显著差异。两组动物均需要补充气体麻醉以利于插管。两种方案均未观察到不良反应或影响；然而，布托啡诺 - 阿扎哌隆 - 美托咪定方案在所有动物中未提供足够的镇静以进行处理，可能不适用于该物种。
