Gokhale Nandan S, Horner Stacy M
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Cell Host Microbe. 2017 Jan 11;21(1):1-2. doi: 10.1016/j.chom.2016.12.013.
In a recent issue of Science, Akiyama et al. (2016) prove the existence of a pseudoknot that stabilizes a nuclease-resistant RNA structure in the 3' untranslated region of Zika virus. This reinforced structure blocks the 5'→3' exonuclease Xrn1 for the production of pathogenic subgenomic flaviviral RNAs.
在最近一期的《科学》杂志上，秋山等人（2016年）证明了一种假结的存在，该假结可稳定寨卡病毒3'非翻译区中一种抗核酸酶的RNA结构。这种强化结构会阻断5'→3'外切核酸酶Xrn1，从而阻止致病性亚基因组黄病毒RNA的产生。
