Song Kyoung Doo
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Clin Mol Hepatol. 2016 Dec;22(4):509-515. doi: 10.3350/cmh.2016.0079.
Local ablation therapy is considered as a conventional treatment option for patients with early stage hepatocellular carcinoma (HCC). Although radiofrequency (RF) ablation is widely used for HCC, the use of cryoablation has been increasing as newer and safer cryoablation systems have developed. The thermodynamic mechanism of freezing and thawing used in cryoablation is the Joule-Thomson effect. Cryoablation destroys tissue via direct tissue destruction and vascular-related injury. A few recent comparative studies have shown that percutaneous cryoablation for HCCs is comparable to percutaneous RF ablation in terms of long term therapeutic outcomes and complications. Cryoablation has several advantages over RF ablation such as well visualization of iceball, no causation of severe pain, and lack of severe damage to great vessels and gallbladder. It is important to know the advantages and disadvantages of cryoablation compared with RF ablation for improvement of therapeutic efficacy and safety.
局部消融治疗被认为是早期肝细胞癌（HCC）患者的一种传统治疗选择。尽管射频（RF）消融已广泛用于肝癌治疗，但随着更新、更安全的冷冻消融系统的发展，冷冻消融的应用一直在增加。冷冻消融中使用的冷冻和解冻的热力学机制是焦耳-汤姆逊效应。冷冻消融通过直接组织破坏和血管相关损伤来破坏组织。最近的一些比较研究表明，就长期治疗效果和并发症而言，经皮冷冻消融治疗肝癌与经皮射频消融相当。与射频消融相比，冷冻消融有几个优点，如冰球可视化良好、不会引起剧痛以及对大血管和胆囊无严重损伤。了解冷冻消融与射频消融相比的优缺点对于提高治疗效果和安全性很重要。
