一种来自小叶买麻藤藤本植物的新型二聚茋类化合物。

A new dimeric stilbene from the lianas of Gnetum parvifolium.

作者信息

Tian Li-Wen, Lv Jun-Jiang, Liu Yao, Song Lu-Yao, Hou Lian-Bing, Zhong Cheng, Xie Yang

机构信息

a School of Pharmaceutical Sciences , Southern Medical University , Guangzhou , People's Republic of China.

b Chemistry and Chemical Engineering college , Chongqing University , Chongqing , People's Republic of China.

出版信息

Nat Prod Res. 2017 Jul;31(13):1495-1500. doi: 10.1080/14786419.2017.1278591. Epub 2017 Jan 12.

DOI:10.1080/14786419.2017.1278591

PMID:28081652

Abstract

A new dimeric stilbene, gnetifolin P (1), was isolated from the lianas of Gnetum parvifolium, together with seven known compounds 2-8. The structure of compound 1 was determined by extensive NMR and HRESIMS data analyses, and quantum chemical calculations. All the compounds were evaluated for their anti-inflammatory activity. Compounds 1 and 6 inhibited the expression of IL-1β on LPS induced THP-1 cells with the inhibition rate of 35.78 and 64.67%, respectively, at concentration of 25 μg/mL.

摘要

从小叶买麻藤的藤本植物中分离出一种新的二聚体芪类化合物——买麻藤黄素P（1），以及七种已知化合物2 - 8。通过广泛的核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）数据分析以及量子化学计算确定了化合物1的结构。对所有化合物的抗炎活性进行了评估。在浓度为25μg/mL时，化合物1和6抑制脂多糖诱导的THP - 1细胞中白细胞介素 - 1β（IL - 1β）的表达，抑制率分别为35.78%和64.67%。