Zadik Yehuda, Elad Sharon, Shapira Anat, Shapira Michael Y
a Department of Oral Medicine, Sedation and Maxillofacial Imaging , Hadassah-Hebrew University School of Dental Medicine , Jerusalem , Israel.
b Department of Oral Medicine , The Oral and Maxillofacial Center, Medical Corps, Israel Defense Forces , Tel Hashomer , Israel.
Expert Opin Pharmacother. 2017 Feb;18(3):235-242. doi: 10.1080/14656566.2017.1282464. Epub 2017 Jan 25.
The oral mucosa is commonly involved in chronic graft-versus-host disease (cGVHD). Oral mucosal cGVHD markedly affect individual's daily function and wellbeing. In some cases, it might become a life threating complication. Areas covered: This article describes the rationale for treatment, method of topical application in the oral cavity, evidence supporting the topical administration of dexamethasone and budesonide for oral cGVHD, and their adverse effects. Expert opinion: Evidence supports the use of topical dexamethasone and budesonide for treatment of oral cGVHD. Topical corticosteroid choice for oral cGVHD, takes into consideration the potency, bioavailability, preferred concentration, and possible adverse effects. Budesonide's pharmacological characteristics mark it as a preferable topical agent for oral cGVHD.
口腔黏膜常累及慢性移植物抗宿主病（cGVHD）。口腔黏膜cGVHD显著影响个体的日常功能和健康。在某些情况下，它可能成为危及生命的并发症。涵盖领域：本文描述了治疗的基本原理、口腔局部应用方法、支持地塞米松和布地奈德局部给药治疗口腔cGVHD的证据及其不良反应。专家意见：有证据支持使用局部地塞米松和布地奈德治疗口腔cGVHD。口腔cGVHD局部皮质类固醇的选择要考虑效力、生物利用度、首选浓度和可能的不良反应。布地奈德的药理学特性使其成为口腔cGVHD更优选的局部用药。
