Jaffrey Samie R, Kharas Michael G
Department of Pharmacology, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA.
Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Genome Med. 2017 Jan 12;9(1):2. doi: 10.1186/s13073-016-0395-8.
N -methyladenosine (mA) in mRNA has emerged as a crucial epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent studies are pointing to a role for the RNA methylation program in cancer self-renewal and cell fate, making this a new and promising therapeutic avenue for investigation.
信使核糖核酸（mRNA）中的N-甲基腺苷（mA）已成为一种关键的表观转录组修饰，可控制细胞分化和多能性。最近的研究表明，RNA甲基化程序在癌症自我更新和细胞命运中发挥作用，使其成为一个新的、有前景的治疗研究途径。
