Department of Gastrointestinal Surgery, Shanghai General Hospital Affiliated to Shanghai Jiaotong University, Shanghai, PR China.
RNA Biol. 2022 Jan;19(1):885-896. doi: 10.1080/15476286.2022.2096793.
The relationship between epitranscriptomics and malignant tumours has become a popular research topic in recent years. N6-methyladenosine (mA), the most common post-transcriptional modification in mammals, is involved in various physiological processes in different cancer types, including gastric cancer (GC). The incidence and mortality of GC have been increasing annually, especially in developing countries. Insights into the epitranscriptomic mechanisms of gastric carcinogenesis could provide potential strategies for the prevention, diagnosis, and treatment of GC. In this review, we describe the mechanisms of RNA m6A modification; the functions of m6A regulators in GC; the functional crosstalk among m6A, messenger RNA, and noncoding RNA; and the promising application of mA in the diagnosis and treatment of GC.
近年来，表观转录组学与恶性肿瘤之间的关系成为研究热点。N6-甲基腺苷（m6A）是哺乳动物中最常见的转录后修饰，参与不同癌症类型（包括胃癌）的多种生理过程。胃癌的发病率和死亡率呈逐年上升趋势，尤其是在发展中国家。深入了解胃癌发生过程中的表观转录组学机制，可为胃癌的预防、诊断和治疗提供潜在策略。本综述描述了 RNA m6A 修饰的机制、m6A 调控因子在胃癌中的功能、m6A、信使 RNA 和非编码 RNA 之间的功能串扰，以及 mA 在胃癌诊断和治疗中的应用前景。
