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急性髓系白血病中的表观遗传修饰：环状 RNA 的新作用（综述）。

Epigenetic modifications in acute myeloid leukemia: The emerging role of circular RNAs (Review).

机构信息

Fujian Institute of Hematology, Fujian Medical Center of Hematology, Clinical Research Center for Hematological Malignancies of Fujian Province, Fuzhou, Fujian 350001, P.R. China.

Medical Intensive Care Unit, Fujian Provincial Hospital, Fuzhou, Fujian 350001, P.R. China.

出版信息

Int J Oncol. 2021 Dec;59(6). doi: 10.3892/ijo.2021.5287. Epub 2021 Nov 18.

DOI:10.3892/ijo.2021.5287
PMID:34792180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8651224/
Abstract

Canonical epigenetic modifications, which include histone modification, chromatin remodeling and DNA methylation, play key roles in numerous cellular processes. Epigenetics underlies how cells that posses DNA with similar sequences develop into different cell types with different functions in an organism. Earlier epigenetic research has primarily been focused at the chromatin level. However, the number of studies on epigenetic modifications of RNA, such as N‑methyladenosine, 2'‑O‑ribosemethylation, inosine, 5‑methylcytidine, N‑methyladenosine (mA) and pseudouridine, has seen an increase. Circular RNAs (circRNAs), a type of RNA species that lacks a 5' cap or 3' poly(A) tail, are abundantly expressed in acute myeloid leukemia (AML) and may regulate disease progression. circRNAs possess various functions, including microRNA sponging, gene transcription regulation and RNA‑binding protein interaction. Furthermore, circRNAs are mA methylated in other types of cancer, such as colorectal and hypopharyngeal squamous cell cancers. Therefore, the critical roles of circRNA epigenetic modifications, particularly mA, and their possible involvement in AML are discussed in the present review. Epigenetic modification of circRNAs may become a diagnostic and therapeutic target for AML in the future.

摘要

经典的表观遗传修饰，包括组蛋白修饰、染色质重塑和 DNA 甲基化，在许多细胞过程中发挥着关键作用。表观遗传学解释了具有相似序列的 DNA 如何使细胞在生物体中发育成具有不同功能的不同细胞类型。早期的表观遗传学研究主要集中在染色质水平。然而，越来越多的研究关注 RNA 的表观遗传修饰，如 N6-甲基腺苷、2′-O-甲基化、肌苷、5-甲基胞嘧啶、N6-甲基腺苷（m6A）和假尿嘧啶。环状 RNA（circRNA）是一种缺乏 5′帽或 3′poly(A)尾的 RNA 物种，在急性髓系白血病（AML）中大量表达，可能调节疾病进展。circRNA 具有多种功能，包括 miRNA 海绵、基因转录调控和 RNA 结合蛋白相互作用。此外，circRNA 在其他类型的癌症中，如结直肠癌和下咽鳞状细胞癌，也发生 m6A 甲基化。因此，本综述讨论了 circRNA 表观遗传修饰（特别是 m6A）的关键作用及其在 AML 中的可能参与。circRNA 的表观遗传修饰可能成为 AML 的未来诊断和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/8651224/3a513b0f072e/IJO-59-06-05287-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/8651224/92ad962dae4f/IJO-59-06-05287-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/8651224/643e4d974b22/IJO-59-06-05287-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/8651224/3a513b0f072e/IJO-59-06-05287-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/8651224/92ad962dae4f/IJO-59-06-05287-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/8651224/643e4d974b22/IJO-59-06-05287-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe32/8651224/3a513b0f072e/IJO-59-06-05287-g02.jpg

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