Murphy Laura C, Millar J Kirsty
Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
Schizophr Res. 2017 Sep;187:55-61. doi: 10.1016/j.schres.2016.12.027. Epub 2017 Jan 9.
Mitochondria are dynamic organelles that are essential to power the process of neurotransmission. Neurons must therefore ensure that mitochondria maintain their functional integrity and are efficiently transported along the full extent of the axons and dendrites, from soma to synapses. Mitochondrial dynamics (trafficking, fission and fusion) co-ordinately regulate mitochondrial quality control and function. DISC1 is a component of the mitochondrial transport machinery and regulates mitochondrial dynamics. DISC1's role in this is adversely affected by sequence variants connected to brain structure/function and disease risk, and by mutant truncation. The DISC1 interactors NDE1 and GSK3β are also involved, indicating a convergence of putative risk factors for psychiatric illness upon mitochondrial dynamics.
线粒体是动态细胞器，对神经传递过程的供能至关重要。因此，神经元必须确保线粒体保持其功能完整性，并能沿着轴突和树突从胞体到突触的全长进行有效运输。线粒体动力学（运输、裂变和融合）协同调节线粒体质量控制和功能。DISC1是线粒体运输机制的一个组成部分，调节线粒体动力学。与脑结构/功能和疾病风险相关的序列变异以及突变截短会对DISC1在这方面的作用产生不利影响。DISC1相互作用蛋白NDE1和GSK3β也参与其中，这表明精神疾病的假定风险因素在 mitochondrial dynamics 上存在汇聚。 （注：原文中“mitochondrial dynamics”可能有误，推测应为“mitochondrial dynamics”，已按此翻译）
