Abrams A M, Melrose R J
Oral Surg Oral Med Oral Pathol. 1978 Aug;46(2):220-33. doi: 10.1016/0030-4220(78)90197-4.
Acinic cell tumors of minor salivary glands are most uncommon. Search of the English language literature revealed twenty previously reported cases. Nine additional cases are newly described. Most patients presented with asymptomatic swellings, but pain and tenderness were experienced by some. Sites of involvement were variable, with the palate, tongue, and floor of the mouth being the most commonly afflicted. One new case occurred centrally within the mandible. There was no sex predominance. A spectrum of histomorphologic characteristics included solid, microcystic, papillary cystic, and follicular patterns composed of acinic, intercalated duct, vacuolated, and nonspecific glandular cells. Follow-up data on ten cases from the literature and the nine new cases revealed that one patient died of tumor, one was alive with distant metastases, and one had been successfully treated for local recurrence. The patient representing the single fatality was treated by irradiation only. Surgical excision with a border of normal tissue seems to be effective treatment. The use of "carcinoma" as an appropriate designation for this neoplasm is questioned.
小唾液腺腺泡细胞肿瘤极为罕见。检索英文文献发现此前有20例报告病例。本文新描述了另外9例病例。大多数患者表现为无症状肿块，但部分患者有疼痛和压痛症状。受累部位各不相同，其中腭部、舌部和口底是最常受累的部位。1例新病例发生在下颌骨中央。无性别差异。一系列组织形态学特征包括由腺泡细胞、闰管细胞、空泡化细胞和非特异性腺细胞组成的实性、微囊状、乳头状囊状和滤泡状结构。来自文献的10例病例及9例新病例的随访数据显示，1例患者死于肿瘤，1例患者存活但有远处转移，1例患者经治疗后局部复发已康复。唯一死亡的患者仅接受了放疗。手术切除并带有正常组织边缘似乎是有效的治疗方法。对于将该肿瘤命名为“癌”是否恰当提出了质疑。
