Blümel Juan Enrique, Arteaga Eugenio, Mezones-Holguín Edward, Zúñiga María Cristina, Witis Silvina, Vallejo María Soledad, Tserotas Konstantino, Sánchez Hugo, Onatra William, Ojeda Eliana, Mostajo Desiree, Monterrosa Alvaro, Lima Selva, Martino Mabel, Hernández-Bueno Jose Alberto, Gómez Gustavo, Espinoza María Teresa, Flores Daniel, Chedraui Peter, Calle Andrés, Bravo Luz María, Benítez Zully, Bencosme Ascanio, Barón Germán
a Collaborative Group for Research of the Climacteric in Latin America (REDLINC) , Santiago , Chile.
b Departamento de Medicina Interna Sur , Facultad de Medicina, Universidad de Chile , Santiago de Chile , Chile , and.
Gynecol Endocrinol. 2017 May;33(5):378-382. doi: 10.1080/09513590.2016.1269741. Epub 2017 Jan 13.
Musculoskeletal pain (MSP) has been recently linked with high plasma leptin levels. Our objective was to study if obese women, who have higher leptin levels, could have a higher frequency of MSP. We studied 6079 Latin-American women, 40-59 years old. Their epidemiological data were recorded and the Menopause Rating Scale (MRS), Golberg Anxiety and Depression Scale and Insomnia Scale were applied. MSP was defined as a score ≥2 on MRS11. Women with MSP were slightly older, had fewer years of schooling and were more sedentary. They also complained of more severe menopausal symptoms (29.2% versus. 4.4%, p < 0.0001). Furthermore, they had a higher abdominal perimeter (87.2 ± 12.0 cm versus 84.6 ± 11.6 cm, p < 0.0001) and a higher prevalence of obesity (23.1% versus 15.2%, p < 0.0001). Compared to normal weight women, those with low body weight (IMC <18.5) showed a lower risk of MSP (OR 0.71; 95%CI, 0.42-1.17), overweight women had a higher risk (OR 1.64; 95%CI, 1.44-1.87) and obese women the highest risk (OR 2.06; 95%CI, 1.76-2.40). Logistic regression analysis showed that obesity is independently associated to MSP (OR 1.34; 95%CI, 1.16-1.55). We conclude that obesity is one identifiable risk factor for MSP in middle-aged women.
肌肉骨骼疼痛（MSP）最近被认为与血浆瘦素水平升高有关。我们的目的是研究瘦素水平较高的肥胖女性是否有更高的MSP发生率。我们研究了6079名40至59岁的拉丁裔女性。记录了她们的流行病学数据，并应用了更年期评定量表（MRS）、戈德堡焦虑和抑郁量表以及失眠量表。MSP被定义为MRS评分≥2。患有MSP的女性年龄稍大，受教育年限较少，且久坐不动。她们还抱怨更年期症状更严重（29.2%对4.4%，p＜0.0001）。此外，她们的腹围更大（87.2±12.0厘米对84.6±11.6厘米，p＜0.0001），肥胖患病率更高（23.1%对15.2%，p＜0.0001）。与正常体重女性相比，体重过低（体质指数＜18.5）的女性患MSP的风险较低（比值比0.71；95%置信区间，0.42 - 1.17），超重女性风险较高（比值比1.64；95%置信区间，1.44 - 1.87），肥胖女性风险最高（比值比2.06；95%置信区间，1.76 - 2.40）。逻辑回归分析表明，肥胖与MSP独立相关（比值比1.34；95%置信区间，1.16 - 1.55）。我们得出结论，肥胖是中年女性MSP的一个可识别风险因素。
